Synchrotrons and X-ray Techniques

This lecture covers the use of synchrotrons and X-ray free-electron lasers in various techniques and applications, focusing on the phase problem. Topics include the Patterson map, molecular replacement, and the use of known folds to determine the structure of proteins. The lecture emphasizes the importance of understanding relative distances and angles between atoms in the unit cell, as well as the process of gluing together blocks of folds to generate structural solutions.