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This lecture delves into the intricate world of the extracellular matrix, focusing on its two fundamental types: interstitial and basement membrane. The discussion covers the composition, function, and significance of these matrices, highlighting the role of proteins like collagen and elastin. The synthesis process, modifications, and assembly of collagen fibers are explored in detail, shedding light on the importance of proper organization for tissue stability. The lecture also touches upon diseases related to collagen, emphasizing the critical role of enzymes in collagen synthesis. Through a comprehensive analysis of the extracellular matrix components, this lecture provides a deep understanding of the structural framework that supports various tissues in the human body.