This lecture covers the interregional interactions within the motor system, including the primary and secondary motor cortex, basal ganglia, cerebellum, and brain stem. It discusses the anatomical connections, functional correlates, and the structural and functional networks involved in motor control. The lecture also explores the concept of forward models in motor behavior, the importance of the motor system in daily life, and the impact of reward on motor learning. Additionally, it delves into the pathological conditions affecting the motor system and the potential interventions to address them.