This lecture explores the use of Transcranial Magnetic Stimulation (TMS) for neuromodulation, focusing on techniques like multifocal stimulation, virtual lesions, and interregional interactions. It delves into the impact of TMS on brain plasticity, interhemispheric connectivity, and motor performance. The lecture also discusses the potential applications of TMS in conditions like stroke, Alzheimer's disease, and cognitive enhancement, emphasizing safety considerations and future directions in TMS research.