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Lecture
Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
This lecture covers the process of neural precursor specification in both invertebrates and vertebrates, detailing the formation of proneural clusters, neuroblasts, and neuronal precursors. It explains the molecular mechanisms involved in neuroectoderm development, including the role of genes like achaete, engrailed, and Notch. The instructor discusses the delamination of neuroblasts, asymmetric cell division, and the specification of neuronal precursors in the central nervous system. Various mutants affecting neurogenesis are also explored, shedding light on the importance of proper neural plate development and the role of key signaling pathways such as Notch. The lecture concludes with insights into the molecular markers and transcription factors crucial for neuronal precursor specification.