Liver Mitochondrial Metabolism: Novel Determinants

This lecture by Kristina Schoonjans explores the novel determinants of liver mitochondrial metabolism, focusing on the liver's role in metabolic homeostasis, the impact of mitochondrial function on energy production, and the regulation of cellular metabolism by SLC25 carriers. The presentation delves into the specific functions of SLC25A47, an hepatocyte-specific mitochondrial carrier, and its implications on glucose metabolism, energy expenditure, and the mitochondrial stress response. The study reveals the critical role of SLC25A47 in liver function and its relationship with FGF21, a key hepatokine involved in metabolic regulation.