Tumor Microenvironment: Stress and Mutation Dependencies

This lecture by the instructor explores the stress and mutation dependencies shaping the tumor microenvironment. It delves into how transcriptional rewiring, driven by mutations in cancer cells and stress responses in the microenvironment, increases phenotypic diversity, tumor fitness, and aggressiveness. The lecture also covers the role of stress responses in promoting tumor survival, fitness, and aggressiveness, focusing on various cell types and factors involved in the process. Additionally, it discusses the activation, heterogeneity, and composition changes of cancer-associated fibroblasts, highlighting their impact on tumor growth, invasion, and immune crosstalk.