Proteomics and Metabolomics: Advanced Techniques and Applications

This lecture covers large-scale proteome profiling with mass spectrometry, experimental design considerations, sources of variability, biomarker discovery, and the importance of robust and automated workflows in protein analysis. It also delves into the significance of biomarkers and proteins in precision medicine, particularly in the context of Alzheimer's disease. The presentation explores the challenges in diagnosing Alzheimer's, the role of biomarkers in disease prediction and treatment, and the potential of lifestyle interventions in reducing dementia risk. Additionally, it discusses the application of mass spectrometry in studying circadian clocks, lipidomics, and metabolomics, highlighting the diverse biological and clinical implications of these advanced techniques.