Organelle Proteins Targeting: VIPs and Peroxisomes

This lecture by the instructor focuses on the systematic cell biology of organelles, particularly on the targeting of Very Important Proteins (VIPs) to organelles. The lecture covers the challenges and mechanisms of protein targeting, with a special emphasis on peroxisomes. Through innovative yeast library strategies and advanced imaging techniques, the instructor and her team have identified new peroxisomal proteins and a novel targeting receptor, Pex9. The lecture also delves into the competition among soluble targeting receptors Pex5, Pex7, and Pex9, revealing insights into the priority targeting of specific proteins. By studying the essential functions of peroxisomes in fatty acid breakdown, the lecture demonstrates how priority targeting ensures cellular functionality even under high targeting loads.