Lecture
This lecture covers the DNA damage checkpoint, focusing on the cell cycle regulation, detection of DNA damage, repair mechanisms, and the role of key proteins such as p53. It explains how the cell cycle is paused to allow DNA repair, the involvement of ATM, ATR, Chk1, and Chk2 kinases, and the activation of repair mechanisms. The lecture also discusses the phosphorylation of histone H2AX, the role of p21 in inhibiting CDK activity, and the overall process of DNA damage response and repair.