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This lecture covers the application of CMOS circuits for DNA detection, focusing on charge-based capacitance measurement methods. Topics include the use of CMOS architectures for VLSI, electrochemical interfaces, capacitance DNA detection, and frequency to capacitance measurement. The instructor discusses the challenges of DNA detection in CBCM mode, the VLSI implementation of the chip, and the impact of overlapping signals. Additionally, the lecture explores the concept of frequency to capacitance measurement, amperometric methods for DNA detection, and the properties of probes in FTCM mode. The presentation concludes with insights on the Taylor series, cyclic voltammetry, and the design of current CMOS readout circuits.