DNA-Encoded Libraries

This lecture covers the principles and techniques of DNA-encoded libraries (DELs) for drug discovery and development. It explains the comparison to biological display techniques, the 'split and pool' synthesis method, and the different DEL synthesis techniques. The lecture also discusses the pros and cons of DELs, the inspiration from biological display techniques, and the synthesis process of DELs. It delves into the diversity of DEL techniques, including split & pool with DNA routing, self-assembled DELs, DNA junctions, and DNA-templated chemistry. The lecture concludes with a case study on the translation of nucleic acid libraries into synthetic compounds for macrocycle library selection.