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This lecture covers the anatomy and physiology of the respiratory system, including the structure and function of the respiratory apparatus in humans, the anatomy of the alveoli, the respiratory barrier, gas exchange, and the transport of oxygen and carbon dioxide in the blood. It also discusses the mechanisms of the ventilatory system, the surfactant in the lungs, the renewal of alveolar air, the diffusion of gases through the respiratory membrane, and the affinity of hemoglobin for oxygen. The lecture delves into the regulation of alveolar ventilation, the diffusion of gases in the peripheral circulation, and the impact of pH on alveolar ventilation.