This lecture covers the concept of optimal signal-to-noise ratio (SNR) in biomedical imaging, focusing on the calculation of the optimum flip angle to maximize the signal. The instructor explains the relationship between SNR, RF pulses, and recovery time (T₁), emphasizing the importance of the Ernst angle. Through theoretical derivations and equilibrium conditions, the lecture demonstrates how the signal depends on parameters such as TR, T₁, and the flip angle. The Ernst angle, introduced by Richard Ernst, is highlighted as a key factor in maximizing the signal intensity. The lecture concludes with practical examples and a tribute to Richard Ernst, a renowned physical chemist.