This lecture covers the principles and techniques of CCD mixing in optical detection systems. It begins with an introduction to CCD registers and the operations involved in crossing and mixing signals. The instructor presents various configurations for crossing CCD registers, detailing the clocking mechanisms for each case. The lecture progresses through three phases of operation, illustrating the effects of different voltage levels on the CCD components. The concept of mixing signals is further explored, demonstrating how to achieve desired outputs through specific layouts and configurations. The instructor emphasizes the importance of adapting clocking speeds for optimal performance in certain cells. Throughout the lecture, practical examples and exercises are provided to reinforce the concepts discussed, ensuring a comprehensive understanding of CCD mixing in optical detection applications.