Cell Plasticity: Transcription Factors and Chromatin State

This lecture explores the concept of cell plasticity, focusing on the role of transcription factors and chromatin state in determining cell identity and fate. It covers key topics such as the hierarchy of stem cells, Waddington's landscape, and the molecular mechanisms behind cell fate determination. The discussion delves into the epigenetic properties of stem cells, the importance of master regulators in cell identity, and the organization of transcription factors in regulatory networks. Additionally, it examines how transcription factors mediate cellular reprogramming and the impact of chromatin organization on gene expression. The lecture concludes with insights into increasing cell plasticity through modifiers of chromatin state and pioneer transcription factors.