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Marcel Leutenegger

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Related publications (67)

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High-Resolution Tracking of Single-Molecule Diffusion in Membranes by Confocalized and Spatially Differentiated Fluorescence Photon Stream Recording

Marcel Leutenegger

The performance of a method is assessed which allows for the spatiotemporal tracking of single dye-labeled molecules during two-dimensional (2D) diffusional transits through the focal area of a modified confocal microscope. In addition to facilitating the ...

Wiley-Blackwell2014

Optical microscopy for biology and life sciences

Theo Lasser, Marcel Leutenegger

Optical microscopy has become a major non- or minimally invasive tool for investigating living organisms such as cells, tissues or small animals. Being such an essential tool for research and because lacking knowledge and insight in the working principles ...

Laboratoire d'Optique Biomédicale, EPFL2014

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A classical technique to monitor dynamical processes at the single-molecule level is fluorescence correlation spectroscopy (FCS). However, FCS requires fluorescent labels that are typically limited by photobleaching and saturation. We present a new method, ...

2013

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We present optical coherence correlation spectroscopy (OCCS), a novel method to study the motion dynamics of nanoparticles within many observation volumes simultaneously. For this purpose, OCCS combines the key features of dark-field optical coherence micr ...

2013

Multiplane 3D superresolution optical fluctuation imaging

Theo Lasser, Marcel Leutenegger, Noelia Laura Bocchio, Aurélien Godinat, Azat Sharipov, Stefan Geissbuehler

By switching fluorophores on and off in either a deterministic or a stochastic manner, superresolution microscopy has enabled the imaging of biological structures at resolutions well beyond the diffraction limit. Superresolution optical fluctuation imaging ...

2013

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Super-resolution optical fluctuation imaging (SOFI) achieves three-dimensional super-resolution by computing higher-order spatio-temporal cross-cumulants of stochastically blink-ing fluorophores. In contrast to localization microscopy, SOFI is compatible w ...

2013

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Super-resolution optical fluctuation imaging (SOFI) achieves 3D super-resolution by computing higher-order cumulants of stochastically blinking fluorophores. In contrast to localization microscopy, SOFI is compatible with weakly emitting fluorophores and a ...

2012

Optical Coherence Correlation Spectroscopy (OCCS)

Theo Lasser, Christophe Pache, Marcel Leutenegger, Arno Pino Bouwens, Stefan Geissbühler, Akihiro Sato, Stéphane Broillet

A classical technique to monitor dynamical processes at the molecular level is fluorescence correlation spectroscopy (FCS). FCS requires fluorescent labels that are typically limited by photobleaching and saturation. We present a new method that uses noble ...

2012

Real-time Full Field Laser Doppler Imaging

Theo Lasser, Marcel Leutenegger, Tyler Nerton Thacher

We present a full field laser Doppler imaging instrument that enables real-time in vivo assessment of blood flow in dermal tissue and skin. The instrument monitors the blood perfusion in an area of about 50cm2 with 480 x 480 pixels per frame at a rate of 1 ...

Amer Inst Physics2012

Fluorescence correlation spectroscopy with a total internal reflection fluorescence STED microscope (TIRF-STED-FCS)

Theo Lasser, Marcel Leutenegger

We characterize a novel fluorescence microscope which combines the high spatial discrimination of a total internal reflection epi-fluorescence (epi-TIRF) microscope with that of stimulated emission depletion (STED) nanoscopy. This combination of high axial ...

Optical Society of America2012