Publications by Jacques Dubochet

Aggregation Behavior of Poly(ethylene glycol-bl-propylene sulfide) Di- and Triblock Copolymers in Aqueous Solution

Jeffrey Alan Hubbell, Conlin O'Neil, Jacques Dubochet

Block copolymers of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-PPS) have recently emerged as a new macromolecular amphiphile capable of forming a wide range of morphologies when dispersed in water. To understand better the relationship between s ...

2009

Bending modes of DNA directly addressed by cryo-electron microscopy of DNA minicircles

John Maddocks, Davide Demurtas, Andrzej Stasiak, Jacques Dubochet, Arnaud Amzallag

We use cryo-electron microscopy (cryo-EM) to study the 3D shapes of 94-bp-long DNA minicircles and address the question of whether cyclization of such short DNA molecules necessitates the formation of sharp, localized kinks in DNA or whether the necessary ...

Oxford University Press2009

Switch-peptides: from conformational studies to Alzheimer's disease

Hilal Lashuel, Karine Murat, Richard Alan Mimna, Jacques Dubochet, Lydiane Jeanine Saucède, Sonia Dos Santos, Marie-Stéphanie Camus, Jérémy Bérard

A review. Studies on designed peptides that exhibit high tendencies for medium-induced conformational transitions have recently attracted much attention because structural changes are considered as mol. key processes in degenerative diseases. The exptl. ac ...

2006

Multifunctional Lipid/Quantum-Dots Hybrid Nanocontainers for Controlled Targeting of Live Cells

Horst Vogel, Pierre-Yves Bolinger, Davide Demurtas, Christophe Danelon, Paulina Izewska, Jacques Dubochet, Gopakumar Gopalakrishnan

In this communication, we report on an interesting observation of wide-ranging potential for cellular imaging and manipulation: Hydrophobic QDs can be easily incorporated into the bilayer membrane of lipid vesicles. Such lipid/QD nanocontainer hybrid vesic ...

Wiley-VCH Verlag GmbH2006