Alke Fink

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Related publications (48)

Superparamagnetic Nanoparticles as a Powerful Systems Biology. Characterization Tool in the Physiological Context

Heinrich Hofmann, Jeffrey Alan Hubbell, Alke Fink, Benedikt Steitz, Marc Moniatte, Conlin O'Neil, Andrija Finka, Jatuporn Salaklang

Recently, functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have been utilized for protein separation and therapeutic delivery of DNA and drugs. The development of new methods and tools for the targeting and identification of specific biom ...

Wiley-Blackwell2008

Engineered nanoparticles for gene delivery in a bleomycin-injured lung fibrosis model

Heinrich Hofmann, Alke Fink

Swiss Medical Publishers Ltd / EMH Swiss Medical Publishers2008

Application of pulsed-magnetic field enhances non-viral gene delivery in primary cells from different origins

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Primary cell lines are more difficult to transfect when compared to immortalized/transformed cell lines, and hence new techniques are required to enhance the transfection efficiency in these cells. We isolated and established primary cultures of synoviocyt ...

2008

Optical properties of annealed Mn2+-doped ZnS nanoparticles

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Yvonne Axmann

Cysteine stabilized ZnS and Mn2+-doped ZnS nanoparticles were synthesized by a wet chemical route. Using the ZnS:Mn2+ nanoparticles as seeds, silica-coated ZnS (ZnS@Si) and ZnS:Mn2+ (ZnS:Mn2+@Si) nanocomposites were formed in water by hydrolysis and conden ...

2008

Solder Doped Polycaprolactone Scaffold Enables Solder Doped Polycaprolactone Scaffold Enables. Reproducible Laser Tissue Soldering

Heinrich Hofmann, Alke Fink, Vianney Bernau

During the last 40 years a focus in research was put on sutureless tissue fusion, to handle the limits of conventional suturing such as vascular wall damage due to the enetrating needle, intraluminal foreign body reactions caused by non-absorbable suture m ...

2008

Superparamagnetic iron oxide nanoparticle coupled tissue soldering

Heinrich Hofmann, Alke Fink, Benedikt Steitz

The invention relates to superparamagnetic iron oxide nanoparticles for use in sutureless thermal mediated tissue fusion. The nanoparticles are dispersed in a biocompatible solder material and heated by application of an alternating electromagnetic field. ...

2007

Superparamagnetic iron oxide nanoparticles (SPIONs): from synthesis to in vivo studies - A summary of the synthesis, characterization, in vitro and in vivo investigations of SPIONs with particular focus on surface and colloidal properties

Heinrich Hofmann, Alke Fink

In this work, we present a short summary of the synthesis and characterization of superparamagnetic iron oxide nanoparticles and their behavior in vitro and in vivo. Therefore, we have used various characterization techniques to deduce the physical particl ...

2007

PRODUCTION AND BIOFUNCTIONALIZATION OF MAGNETIC NANOBEADS FOR MAGNETIC SEPARATION OF MESSENGER RNA

Heinrich Hofmann, Alke Fink, Benedikt Steitz

The synthesis of nanosized beads of superparamagnetic iron oxide nanoparticles coated with 3-(aminopropyl)triethoxysilane is reported in this paper. The resulting beads are agglomerates of SPIONs with an open fractal like structure. These beads have been e ...

2007

Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): Implications on imaging of atherosclerotic plaques

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Introduction: Superparamagnetic iron oxide nanoparticles (SPIONs) have been successfully used for magnetic resonance imaging (MRI) of atherosclerotic plaques. Endocytosis into monocytes/macrophages has been proposed as the mechanism for SPION uptake, but a ...

2007

Characterization of PEI-coated superparamagnetic iron oxide nanoparticles for transfection: Size distribution, colloidal properties and DNA interaction

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Superparamagnetic iron oxide nanoparticles (SPIONs) were coated with polyethylenimine. Here, we briefly describe the synthesis as well as DNA:PEI:SPION complexes and the characterization of the compounds according to their particle size, zeta-potential, mo ...

2007

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