Publications by Caroline Vandevyver

A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song

A versatile and robust method for the determination of DNA and PCR products (

2008

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song

The cellular uptake mechanism and intracellular distribution of emissive lanthanide helicates have been elucidated by time-resolved luminescence microscopy (TRLM). The helicates are non-cytotoxic and taken up by normal (HaCat) and cancer (HeLa, MCF-7) cell ...

2008

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver

A new macrocyclic ligand,

L^3

, has been synthesised, based on the cyclen framework grafted with three phenacyl light-harvesting groups and a C5-alkyl chain bearing a carboxylic acid function as a potential linker for biological material. Acidity constant ...

2007

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

The homoditopic ligand

H_2L^{C3}

has been designed to form neutral triple-stranded bimetallic helicates of overall composition [

Ln_2(L^{C3})_3

]. The grafting of the polyoxyethylene fragments ensures water solubility and also favors cell penetration whi ...

2007

On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system

Martinus Gijs, Ulrike Lehmann, Damien de Courten, Virendra Kumar Parashar, Caroline Vandevyver

Miniaturized system for bioanalysis have been constantly gaining importance and interest within the recent years. The reduction of sample consumption and reaction time are some of the major advantages of such lab-on-a-chip applications. One of the greatest ...

2007

New Opportunities for Lanthanide Luminescence

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Steve Comby

Trivalent lanthanide ions display fascinating optical properties. The discovery of the corresponding elements and their fist industrial uses were intimately linked to their optical properties. This relationship has been kept alive until today when many hig ...

2007

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

Martinus Gijs, Ulrike Lehmann, Virendra Kumar Parashar, Caroline Vandevyver

We present a new approach for the manipulation of small liquid samples for the miniaturization of bioanalytical systems. In our system, minute liquid volumes are manipulated via the interaction of a changeable magnetic field and magnetic microparticles con ...

2007

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Jean-Claude Bünzli, Caroline Vandevyver

A new polydentate tripodal ligand T2soxMe was synthesized to take advantage of the chelating effect of tridentate 8- hydroxyquinolinate subunits. Potentiometric and spectrophotometric titrations reveal seven pKa values of between 3.7 and 10.2. In water, th ...

2007

Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Steve Comby

Water-soluble triple-stranded [Ln2(L)3] helicates have been successfully tested as imaging probes in human cervical adenocarcinoma cells (HeLa), the complex being not toxic and clearly staining their cytoplasm in a concentrationdependent manner. ...

2007

Two-dimensional magnetic manipulation of microdroplets on a chip as a platform for bioanalytical applications

Martinus Gijs, Ulrike Lehmann, Amar Rida, Virendra Kumar Parashar, Caroline Vandevyver

Manipulating biological samples in microliter droplets has vast potential in molecular diagnostics. We present a system for the two-dimensional (2D) magnetic manipulation of aqueous droplets suspended in silicone oil as a platform for on-chip bioanalysis. ...

2006

Caroline Vandevyver

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A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system

New Opportunities for Lanthanide Luminescence

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes

Two-dimensional magnetic manipulation of microdroplets on a chip as a platform for bioanalytical applications

A Novel Strategy for the Design of 8-Hydroxyquinolinate- Based Lanthanide Bioprobes That Emit in the Near Infrared Range

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

New Opportunities for Lanthanide Luminescence

Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes

Two-dimensional magnetic manipulation of microdroplets on a chip as a platform for bioanalytical applications

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system