Person

Nicolas Jean Philippe Guex

Related publications (23)

DBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies

Nicolas Jean Philippe Guex, Murielle Bochud, Cristian Carmeli, Aurélien Thomas, Tiziana Caputo

As a powerful phenotyping technology, metabolomics provides new opportunities in biomarker discovery through metabolome-wide association studies (MWAS) and the identification of metabolites having a regulatory effect in various biological processes. While ...

2021

Predicting spatial patterns of soil bacteria under current and future environmental conditions

Nicolas Jean Philippe Guex, Jan Roelof van der Meer, Marco Pagni, Aline Buri

Soil bacteria are largely missing from future biodiversity assessments hindering comprehensive forecasts of ecosystem changes. Soil bacterial communities are expected to be more strongly driven by pH and less by other edaphic and climatic factors. Thus, al ...

2021

Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss

Nicolas Jean Philippe Guex

Non-Syndromic Hereditary Hearing Loss (NSHHL) is a genetically heterogeneous sensory disorder with about 120 genes already associated. Through exome sequencing (ES) and data aggregation, we identified a family with six affected individuals and one unrelate ...

2021

Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

Melanie Blokesch, Nicolas Jean Philippe Guex, Christian Iseli, Sandrine Stutzmann, Candice Stoudmann, Noémie Matthey

Natural competence for transformation is a primary mode of horizontal gene transfer. Competent bacteria are able to absorb free DNA from their surroundings and exchange this DNA against pieces of their own genome when sufficiently homologous. However, the ...

2019

Differential regulation of RNA polymerase III genes during liver regeneration

Olivier Martin, Bart Deplancke, Felix Naef, Jacques Rougemont, Nicolas Jean Philippe Guex, Marion Leleu, Fabrice David, Winship Herr, Mauro Delorenzi, Kyle Gustafson, Dominic Villeneuve, Cristian Carmeli, Sunil Kumar Raghav, Nouria Hernandez, Laura Symul, Irina Krier, Julien Delafontaine, Philippe Jacquet, Julia Catharina Cajan, Maykel Lopes, Ioannis Xenarios, François Mange

Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcriptio ...

Oxford University Press (OUP)2019

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Nicolas Jean Philippe Guex, Nadine Fournier, Miguel Garcia, Etienne Meylan, Alessandra Piersigilli, Julien Robert Rémi Faget, Inti Zlobec, Gael Luis Boivin, Svenja Johanna Groeneveld, Loïc Steiner, Ioannis Xenarios

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1 + neutrophils to disease ...

Cell Press2017

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer

George Coukos, Nicolas Jean Philippe Guex, Luc Henry, Ioannis Xenarios, Hans-Anton Lehr, Nathalie Rufer, Emanuela Marina Iancu

In experimental mouse models of cancer, increasingly compelling evidence point toward a contribution of tumor associated macrophages (TAM) to tumor lymphangiogenesis. Corresponding experimental observations in human cancer remain scarce although lymphatic ...

Taylor & Francis Inc2016

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

Olivier Martin, Vassily Hatzimanikatis, Jacques Rougemont, Giovanna Ambrosini, Nicolas Jean Philippe Guex, Marion Leleu, Nadine Fournier, Krisztian Homicsko, Julien Dorier, Christian Iseli, Fabrice David, Maxime Jan, Sophie Barret, Philipp Bucher, Mauro Delorenzi, Julien Racle, David Gfeller, João Pedro de Matos Rodrigues, Thomas Junier, Niklaus Johner, René Dreos, Rouayda Cavin Perier, Omid Shahmirzadi, Romain Fernand Pietro Groux, Ray Marcel Marin Florez, Somi Reddy Majjigapu, Christophe Bovigny, Marco Pagni, Julien Delafontaine, Sunil Kumar, Delphine Yvette L Grun, Philippe Jacquet, Philippe Moret, Haleh Yasrebi, Daniel Federico Hernandez Gardiol, Samuel Neuenschwander, Heinz Stockinger, Sebastian Schmidt, Lucila Aimo, Yoann Mouscaz, Sara Benmohammed, Thierry Lombardot, Patrick Roelli, Benjamin Paccaud, Linda Dib, Ioannis Xenarios, Olivier Michielin, Amos Bairoch, Thierry Sengstag, Andreas Schmid, Frederic Burdet, Aline Dousse, Madeleine Suffiotti, Nicolas Salamin, Grégoire Rossier, Daniel Schmocker, Atul Sethi, Guillaume Keller, Felipe Aristides Simao Neto, Ni Ai, Leonore Wigger, Marie Ghraichy, Saumya Gupta, Rounak Vyas, Thomas Stricker

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to t ...

Oxford University Press2016

Differential Dimerization of Variants Linked to Enhanced S-Cone Sensitivity Syndrome (ESCS) Located in the NR2E3 Ligand-Binding Domain

Nicolas Jean Philippe Guex, Pascal Escher

NR2E3 encodes the photoreceptor-specific nuclear hormone receptor that acts as a repressor of cone-specific gene expression in rod photoreceptors, and as an activator of several rod-specific genes. Recessive variants located in the ligand-binding domain (L ...

Wiley-Blackwell2015

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Olivier Martin, Gerardo Turcatti, Nicolas Jean Philippe Guex, Marc Chambon

The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high-content genome-wide RNAi screens that monit ...

Nature Publishing Group2015

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