Jean-Charles Bensadoun

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Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

Patrick Aebischer, Jean-Charles Bensadoun, Eric Garrison Fine, Nicole Déglon

Glial cell line-derived neurotrophic factor (GDNF) holds great promise for the treatment of Parkinson's disease. In humans, its intracerebroventricular administration leads to limiting side effects. Direct parenchymal delivery using mechanical means, or ce ...

2003

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

Patrick Aebischer, Jean-Charles Bensadoun, Nicole Déglon

Ciliary neurotrophic factor prevents behavioural deficits and striatal degeneration in rat and primate models of Huntington's disease. Interleukin- 6, another member of the cytokine family, and the chimeric molecule (IL6/IL6R) in which interleukin-6 and it ...

2001

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

Didier Trono, Patrick Aebischer, Romain Zufferey, Jean-Charles Bensadoun

Glial cell line-derived neurotrophic factor (GDNF) is able to protect dopaminergic neurons against various insults and constitutes therefore a promising candidate for the treatment of Parkinson's disease. Lentiviral vectors that infect quiescent neuronal c ...

2000

Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF

Patrick Aebischer, Jean-Charles Bensadoun, Nicole Déglon

Local delivery of therapeutic molecules represents one of the limiting factors for the treatment of neurodegenerative disorders. In vivo gene transfer using viral vectors constitutes a powerful strategy to overcome this limitation. The aim of the present s ...

2000

Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

Patrick Aebischer, Jean-Charles Bensadoun

Normal cellular metabolism produces oxidants which are neutralized within cells by antioxidant enzymes and other antioxidants. An imbalance between oxidants and antioxidants has been postulated to lead to the degeneration of specific populations of neurons ...

1998

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Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

Patrick Aebischer, Jean-Charles Bensadoun, Eric Garrison Fine, Nicole Déglon

2003

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

Patrick Aebischer, Jean-Charles Bensadoun, Nicole Déglon

2001

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

Didier Trono, Patrick Aebischer, Romain Zufferey, Jean-Charles Bensadoun

2000

Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF

Patrick Aebischer, Jean-Charles Bensadoun, Nicole Déglon

2000

Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

Patrick Aebischer, Jean-Charles Bensadoun

1998