Jean-Charles Bensadoun

This person is no longer with EPFL

About
Privacy
Disclaimer

Graph Chatbot

Related publications (25)

KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

Maria del Carmen Sandi Perez, Didier Trono, Maria Isabel Cordero Campana, Jean-Charles Bensadoun, Reto Bisaz, Anna Claire Groner, Johan Jakobsson

KAP1 is an essential cofactor of KRAB-zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. Here, we report that KAP1 is expressed at high levels and ...

2008

Demonstration of cortical recording using novel flexible polymer neural probes

Philippe Renaud, Arnaud Bertsch, André Mercanzini, Philippe Colin, Marc Jasper Boers, Jean-Charles Bensadoun, Karen Cheung

We present the fabrication, characterization, use in cortical recording and histological results of a flexible implantable neural probe. The microfabricated device is implemented in polyimide and platinum providing mechanical flexibility, high quality elec ...

2008

Demonstration of cortical recording and reduced inflammatory response using flexible polymer neural probes

Philippe Renaud, Arnaud Bertsch, André Mercanzini, Philippe Colin, Marc Jasper Boers, Jean-Charles Bensadoun, Karen Cheung

2007

Controlled Release Drug Coatings on Flexible Neural Probes

Philippe Renaud, Arnaud Bertsch, André Mercanzini, Jeffrey Alan Hubbell, Philippe Colin, Jean-Charles Bensadoun

We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biod ...

2007

Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

Patrick Aebischer, Jean-Charles Bensadoun, Nicole Déglon

Reactive oxygen species are considered to contribute to the pathogenesis of Parkinson's disease (PD). In order to study viral vector-mediated overexpression of the antioxidant enzyme glutathione peroxidase (GPX) as a potential neuroprotective approach in b ...

2006

Viral vectors as a tool to model and treat Parkinson's disease

Patrick Aebischer, Jean-Charles Bensadoun

2006

Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease

Patrick Aebischer, Jean-Charles Bensadoun, Bernard Schneider, Christophe Lo Bianco

Numerous studies have shown the neuroprotective and regenerative benefits of glial cell line-derived neurotrophic factor (GDNF) in animal models of PD. Brain delivery of GDNF can, however, be associated with limiting side-effects in both primates and PD pa ...

2006

Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor

Patrick Aebischer, Jean-Charles Bensadoun

We investigated whether a continuous supply of glial cell line-derived neurotrophic factor (GDNF) via encapsulated genetically modified cells can promote survival and fiber outgrowth from xenotransplanted human dopaminergic neurons. Cells genetically engin ...

2005

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS

Patrick Aebischer, Jean-Charles Bensadoun, Sandrine Guillot

Mutations in Cu/Zn superoxide dismutase (encoded by SOD1), one of the causes of familial amyotrophic lateral sclerosis (ALS), lead to progressive death of motoneurons through a gain-of-function mechanism. RNA interference (RNAi) mediated by viral vectors a ...

2005

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

Patrick Aebischer, Jean-Charles Bensadoun, Nicole Déglon, Diana Zala

Ciliary neurotrophic factor (CNTF) has been shown to prevent behavioral deficits and striatal degeneration in neurotoxic models of Huntington's disease (HD), but its effect in a genetic model has not been evaluated. Lentiviral vectors expressing the human ...

2004

Page 2 of 3