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Pascal Jourdain

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Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Pascal Jourdain, Jean-Marie Petit, Jiangyan Yang

L-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism invo ...

National Academy of Sciences2014

Lactate Modifies Neuronal Excitability Through Both Nmda And Katp Receptors: Importance For Plasticity Genes Expression

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Pascal Jourdain, Jean-Marie Petit, Jiangyan Yang

Wiley-Blackwell2013

Marker-free phase nanoscopy

Pierre Magistretti, Christian Depeursinge, Pierre Marquet, Nicolas Pavillon, Pascal Jourdain, Daniel Boss, Yann Jérôme Michel Pascal Cotte, Muhammed Fatih Toy

We introduce a microscopic method that determines quantitative optical properties beyond the optical diffraction limit and allows direct imaging of unstained living biological specimens. In established holographic microscopy, complex fields are measured us ...

Nature Publishing Group2013

Lactate As A Signaling Molecule For The Regulation Of Plasticity-Related Genes Expression

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Pascal Jourdain, Jean-Marie Petit, Jiangyan Yang

Wiley-Blackwell2013

Lactate as a signaling molecule for the regulation of plasticity-related genes expression

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Pascal Jourdain, Jean-Marie Petit, Jiangyan Yang

Wiley-Blackwell2013

Measurement of absolute cell volume, osmotic membrane water permeability, and refractive index of transmembrane water and solute flux by digital holographic microscopy

Pierre Magistretti, Christian Depeursinge, Pierre Marquet, Pascal Jourdain, Daniel Boss

A dual-wavelength digital holographic microscope to measure absolute volume of living cells is proposed. The optical setup allows us to reconstruct two quantitative phase contrast images at two different wavelengths from a single hologram acquisition. When ...

SPIE Society of Photo-optical Instrumentation Engineers2013

Simultaneous Optical Recording in Multiple Cells by Digital Holographic Microscopy of Chloride Current Associated to Activation of the Ligand-Gated Chloride Channel GABA(A) Receptor

Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Pascal Jourdain, Daniel Boss, Corinne Moratal

Chloride channels represent a group of targets for major clinical indications. However, molecular screening for chloride channel modulators has proven to be difficult and time-consuming as approaches essentially rely on the use of fluorescent dyes or invas ...

Public Library of Science2012

Early Cell Death Detection with Digital Holographic Microscopy

Pierre Magistretti, Christian Depeursinge, Pierre Marquet, Nicolas Pavillon, Pascal Jourdain, Corinne Moratal

Background: Digital holography provides a non-invasive measurement of the quantitative phase shifts induced by cells in culture, which can be related to cell volume changes. It has been shown previously that regulation of cell volume, in particular as it r ...

Public Library of Science2012

What role in cerebral activity?

Pierre Magistretti, Pierre Marquet, Pascal Jourdain

2012

Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Co-transporters KCC2 and NKCC1: A Digital Holographic Microscopy Study

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Nicolas Pavillon, Pascal Jourdain, Daniel Boss, Corinne Moratal

Digital holographic microscopy (DHM) is a noninvasive optical imaging technique that provides quantitative phase images of living cells. In a recent study, we showed that the quantitative monitoring of the phase signal by DHM was a simple label-free method ...

Society for Neuroscience2011

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Measurement of absolute cell volume, osmotic membrane water permeability, and refractive index of transmembrane water and solute flux by digital holographic microscopy

Pierre Magistretti, Christian Depeursinge, Pierre Marquet, Pascal Jourdain, Daniel Boss

SPIE Society of Photo-optical Instrumentation Engineers2013

What role in cerebral activity?

Pierre Magistretti, Pierre Marquet, Pascal Jourdain

2012

Early Cell Death Detection with Digital Holographic Microscopy

Pierre Magistretti, Christian Depeursinge, Pierre Marquet, Nicolas Pavillon, Pascal Jourdain, Corinne Moratal

Public Library of Science2012

Determination of Transmembrane Water Fluxes in Neurons Elicited by Glutamate Ionotropic Receptors and by the Co-transporters KCC2 and NKCC1: A Digital Holographic Microscopy Study

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Nicolas Pavillon, Pascal Jourdain, Daniel Boss, Corinne Moratal

Society for Neuroscience2011

Simultaneous Optical Recording in Multiple Cells by Digital Holographic Microscopy of Chloride Current Associated to Activation of the Ligand-Gated Chloride Channel GABA(A) Receptor

Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Pascal Jourdain, Daniel Boss, Corinne Moratal

Public Library of Science2012