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Thierry Laroche

Related publications (39)

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W2S: Microscopy Data with Joint Denoising and Super-Resolution for Widefield to SIM Mapping

Sabine Süsstrunk, Daniel Sage, Thierry Laroche, Arne Seitz, Majed El Helou, Ruofan Zhou

In fluorescence microscopy live-cell imaging, there is a critical trade-off between the signal-to-noise ratio and spatial resolution on one side, and the integrity of the biological sample on the other side. To obtain clean high-resolution (HR) images, one ...

2020

Development of Sample-Adaptable Holders for Lightsheet Microscopy

Thierry Laroche, Olivier Burri, Arne Seitz, Lalit Kumar Dubey

Multi-user core microscopy facilities are often faced with the challenge to adapt or modify existing instruments. This is essential in order to fulfill the requirements of the user community, who wants to image a wide range of model organisms with varying ...

FRONTIERS MEDIA SA2019

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Benzothiazinones (BTZ) are highly potent bactericidal inhibitors of mycobacteria and the lead compound, BTZ043, and the optimized drug candidate, PBTZ169, have potential for the treatment of tuberculosis. Here, we exploited the tractability of the BTZ scaf ...

2018

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Cell-cell fusion is essential for fertilization. For fusion of walled cells, the cell wall must be degraded at a precise location but maintained in surrounding regions to protect against lysis. In fission yeast cells, the formin Fus1, which nucleates linea ...

Rockefeller Univ Press2015

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The glyoxalase system is the most important pathway for the detoxification of methylglyoxal (MG), a highly reactive dicarbonyl compound mainly formed as a by-product of glycolysis. MG is a major precursor of advanced glycation end products (AGEs), which ar ...

2011

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

Pierre Magistretti, Hilal Lashuel, Igor Allaman, Thierry Laroche, David Viertl

Amyloid-beta (Abeta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little is known about their influence on glial cells. Astrocytes play a pivotal role in brain homeostas ...

2010

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Photosensitive probes are powerful tools to study cellular processes with high temporal and spatial resolution. However, most synthetic fluorophores suited for biomolecular imaging have not been converted yet to appropriate photosensitive analogues. Here w ...

American Chemical Society2010

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Conventional in situ hydrogel micropatterning techniques work successfully for relatively stiff hydrogels, but they often result in locally damaged surfaces upon demolding in the case of soft and fragile polymer networks formed at low precursor concentrati ...

American Chemical Society2009

Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression

Thierry Laroche

The mechanism of chromatin compaction in mitosis has been well studied, while little is known about what controls chromatin decompaction in early G1 phase. We have localized the Condensin subunit Brn1 to a compact spiral of rDNA in mitotic budding yeast ce ...

Nature Publishing Group2009

Theory of molecular excitation and relaxation near a plasmonic device

Olivier Martin, Thierry Laroche

The new optical concepts currently developed in the research field of plasmonics can have significant practical applications for integrated optical device miniaturization as well as for molecular sensing applications. Particularly, these new devices can of ...

2007