Person
Olexiy Kochubey
Related publications (16)
A striatal circuit balances learned fear in the presence and absence of sensory cues
Ralf Schneggenburger, Olexiy Kochubey, Michael Kintscher
During fear learning, defensive behaviors like freezing need to be finely balanced in the presence or absence of threat-predicting cues (conditioned stimulus, CS). Nevertheless, the circuits underlying such balancing are largely unknown. Here, we investiga ...
eLIFE SCIENCES PUBL LTD2023Stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsins yields opposite behavioral outcomes
Ralf Schneggenburger, Olexiy Kochubey, Aiste Baleisyte
The medial amygdala (MeA) receives pheromone information about conspecifics and has crucial functions in social behaviors. A previous study showed that activation of GABA neurons in the postero-dorsal MeA (MeApd) with channelrhodopsin-2(H)(134R) (ChR2) sti ...
CELL PRESS2022A VTA to Basal Amygdala Dopamine Projection Contributes to Signal Salient Somatosensory Events during Fear Learning
Ralf Schneggenburger, Olexiy Kochubey, Wei Tang, Michael Kintscher
The amygdala is a brain area critical for the formation of fear memories. However, the nature of the teaching signal(s) that drive plasticity in the amygdala are still under debate. Here, we use optogenetic methods to investigate the contribution of ventra ...
2020Insular cortex processes aversive somatosensory information and is crucial for threat learning
Ralf Schneggenburger, Olexiy Kochubey, Denys Osypenko, Wei Tang, Michael Kintscher, Shriya Palchaudhuri, Emmanuelle Marie Brigitte Berret
Learning about threats is essential for survival. During threat learning, an innocuous sensory percept such as a tone acquires an emotional meaning when paired with an aversive stimulus such as a mild footshock. The amygdala is critical for threat memory f ...
AMER ASSOC ADVANCEMENT SCIENCE2019Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons
Ralf Schneggenburger, Olexiy Kochubey, Enida Gjoni, Brice Antoine Alexandre Bouhours
Parvalbumin-expressing inhibitory neurons in the mammalian CNS are specialized for fast transmitter release at their output synapses. However, the Ca2+ sensor(s) used by identified inhibitory synapses, including the output synapses of parvalbumin-expressin ...
2017A Synaptotagmin Isoform Switch during the Development of an Identified CNS Synapse
Ralf Schneggenburger, Olexiy Kochubey, Zsolt Norbert Babai
Various Synaptotagmin (Syt) isoform genes are found in mammals, but it is unknown whether Syts can function redundantly in a given nerve terminal, or whether isoforms can be switched during the development of a nerve terminal. Here, we investigated the pos ...
2016An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse
Henry Markram, Felix Schürmann, Ralf Schneggenburger, Daniel Keller, Olexiy Kochubey, Yunyun Han, Zsolt Norbert Babai
The spatial arrangement of Ca2+ channels and vesicles remains unknown for most CNS synapses, despite of the crucial importance of this geometrical parameter for the Ca2+ control of transmitter release. At a large model synapse, the calyx of Held, transmitt ...
Public Library Science2015Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release
Ralf Schneggenburger, Olexiy Kochubey, Özgür Genç
Transmitter release at synapses is regulated by preceding neuronal activity, which can give rise to short-term enhancement of release like post-tetanic potentiation (PTP). Diacylglycerol (DAG) and Protein-kinase C (PKC) signaling in the nerve terminal have ...
Elife Sciences Publications Ltd2014An Alien Divalent Ion Reveals a Major Role for Ca2+ Buffering in Controlling Slow Transmitter Release
Ralf Schneggenburger, Daniel Keller, Olexiy Kochubey, Zsolt Norbert Babai
Ca2+-dependent transmitter release occurs in a fast and in a slow phase, but the differential roles of Ca2+ buffers and Ca2+ sensors in shaping release kinetics are still controversial. Replacing extracellular Ca2+ by Sr2+ causes decreased fast release but ...
2014Ca2+ channels and transmitter release at the active zone
Ralf Schneggenburger, Olexiy Kochubey, Yunyun Han
Ca2+-dependent transmitter release is the most important signaling mechanism for fast information transfer between neurons. Transmitter release takes places at highly specialized active zones with sub-micrometer dimension, which contain the molecular machi ...
Elsevier2012