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Lorène Aeschbach

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Lorène Aeschbach

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Comparative Analysis of Total Alpha-Synuclein (alpha SYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified alpha SYN Proteoforms

N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease

Highly efficient production of the Alzheimer's γ-Secretase integral membrane protease complex by a multi-gene stable integration approach

Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified gamma-Secretase Complexes

Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease