Lee Ann Laurent-Applegate

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Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels

Dominique Pioletti, Peyman Karami, Lee Ann Laurent-Applegate

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage r ...

MDPI2024

Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine

Sandra Jaccoud, Corinne Scaletta, Philippe Abdel Sayed, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri, Laurent Alexis Clément Vannay, Cédric Peneveyre, Annick Jeannerat, Alexis Laurent, Joachim Meuli

Hand tendon/ligament structural ruptures (tears, lacerations) often require surgical reconstruction and grafting, for the restauration of finger mechanical functions. Clinical-grade human primary progenitor tenocytes (FE002 cryopreserved progenitor cell so ...

MDPI2023

Industrial Biotechnology Conservation Processes: Similarities with Natural Long-Term Preservation of Biological Organisms

Philippe Abdel Sayed, Corinne Scaletta, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri, Laurent Alexis Clément Vannay, Alexis Laurent

Cryopreservation and lyophilization processes are widely used for conservation purposes in the pharmaceutical, biotechnological, and food industries or in medical transplantation. Such processes deal with extremely low temperatures (e.g., -196 degrees C) a ...

MDPI2023

Loading Induced Self-Heating Of Articular Cartilage And Associated Signaling Mechanism

Dominique Pioletti, Lee Ann Laurent-Applegate, Naser Nasrollahzadeh Mamaghani

MARY ANN LIEBERT, INC2022

Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications

Dominique Pioletti, Nathalie Hirt-Burri, Lee Ann Laurent-Applegate, Jens Antons, Cédric Peneveyre, Pierre-Arnaud Aeberhard, Anthony Grognuz

Chronic and acute tendon injuries are frequent afflictions, for which treatment is often long and unsatisfactory. When facing extended injuries, matrices and scaffolds with sufficient biomechanical properties are required for surgical repair and could addi ...

2020

Depth-dependent mechanical properties of human articular cartilage obtained by indentation measurements

Pierre-Etienne Bourban, Lee Ann Laurent-Applegate, Matteo Gregorio Modesto Marascio, Robin Martin, Jens Antons

Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is li ...

2018

Development of an effective cell seeding technique: simulation, implementation and analysis of contributing factors

Dominique Pioletti, Lee Ann Laurent-Applegate, Naser Nasrollahzadeh Mamaghani

Cell seeding in a biomaterial is an important process for tissue engineering applications. It helps to modulate tissue formation or to control initial conditions for mechanobiological studies. The compression release-induced suction (CRIS) seeding techniqu ...

Mary Ann Liebert, Inc2017

Human bone progenitor cells for clinical application: what kind of immune reaction does fetal xenograft tissue trigger in immuno-competent rats?

Dominique Pioletti, Lee Ann Laurent-Applegate, Tanja Cloé Hausherr

The potential of human fetal bone cells for successful bone regeneration has been shown in vivo. In particular, it has been demonstrated that the seeding of these cells in porous poly-(L-lactic acid)/ ß-tricalcium phosphate scaffolds improved the bone form ...

Cognizant Communication Corp2017

Stability enhancement using hyaluronic acid gels for delivery of human fetal progenitor tenocytes

Dominique Pioletti, Alain Farron, Corinne Scaletta, Lee Ann Laurent-Applegate, Anthony Grognuz

Tendon afflictions are very common, and their negative impact is high both at the workplace and in leisure activities. Tendinopathies are increasing in prevalence and can lead to tendon ruptures, where healing is a long process with outcomes that are often ...

2016

Anti-microbial dendrimers against multidrug-resistant P. aeruginosa enhance the angiogenic effect of biological burn-wound bandages

Dominique Pioletti, Philippe Abdel Sayed, Lee Ann Laurent-Applegate, Jean-Louis Reymond, Paris Jafari

Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with signi cant morbidity ...

Nature Research2016

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