Lee Ann Laurent-Applegate

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Related publications (24)

Epiphyseal chondro-progenitors provide a stable cell source for cartilage cell therapy

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Salim Elias Darwiche

Articular cartilage regeneration poses particularly tough challenges for implementing cell-‐based therapies. Many cell types have been investigated looking for a balanced combination of responsiveness and stability, yet techniques are still far from defin ...

2012

Biologicals and fetal cell therapy for wound healing and scar management

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri

Few biopharmaceutical preparations developed from biologicals are available for tissue regeneration and scar management. When developing biological treatments with cellular therapy, selection of cell types and establishment of consistent cell banks are cru ...

2011

Human fetal bone cells in delivery systems for bone engineering

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Sandra Jaccoud, Nathalie Hirt-Burri

The aim of this study was to culture human fetal bone cells (dedicated cell banks of fetal bone derived from 14 week gestation femurs) within both hyaluronic acid gel and collagen foam, to compare the biocompatibility of both matrices as potential delivery ...

Wiley-Blackwell2011

Regulation of proliferation and differentiation of human fetal bone cells

Dominique Pioletti, Lee Ann Laurent-Applegate

During the last decade, extensive research has been performed in the field of orthopedic medicine to develop cell-based therapies for the restoration of injured bone tissue. We previously demonstrated that human primary fetal bone cells (HFBCs) associated ...

2011

Plasticity of fetal cartilaginous cells

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Sandra Jaccoud, Aurélie Quintin

Tissue-specific stem cells found in adult tissues can participate to the repair process following injury. However adult tissues, such as articular cartilage and intervertebral disc, have low regeneration capacity, whereas fetal tissues, such as articular c ...

2010

Whole-cell bioprocessing of human fetal cells for tissue engineering of skin

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri

Current restrictions for human cell-based therapies have been related to technological limitations with regards to cellular proliferation capacity (simple culture conditions), maintenance of differentiated phenotype for primary human cell culture and trans ...

2009

In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate

We describe herein some immunological properties of human fetal bone cells recently tested for bone tissue engineering applications. Adult mesenchymal stem cells and adult osteoblasts were included in the study for comparison. Surface markers involved in b ...

2009

Isolation and in vitro chondrogenic potential of human fetal spine cells

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Sandra Jaccoud, Aurélie Quintin

Cell therapy for nucleus pulposus regeneration is an attractive treatment for early disc degeneration as shown by studies using autologous nucleus pulposus cells or stem cells. Another potential source of cells is fetal cells. We investigated the feasibili ...

2009

Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri

Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can ...

2009

Wound healing gene-family expression differences between fetal and foreskin cells used for bioengineered skin substitutes

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri

For tissue engineering, several cell types and tissues have been proposed as starting material. Allogenic skin products available for therapeutic usage are mostly developed with cell culture and with foreskin tissue of young individuals. Fetal skin cells o ...

2008

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