Publications by Sean Lewis Hill

BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

Pascal Fua, Sean Lewis Hill, Jiancheng Yang, Xiang Li, Amos Sironi, Jian Zhou, Jie Zhou, Siqi Liu

BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species that is representative of the data obtained in m ...

2023

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Henry Markram, Sean Lewis Hill, Michael Reimann, Rodrigo de Campos Perin, James Gonzalo King, Ying Shi, Rajnish Ranjan, Mustafa Anil Tuncel, Samuel Claude Kerrien, Polina Litvak

2023

Technology-Enabled Collaborative Care for Concurrent Diabetes and Distress Management During the COVID-19 Pandemic: Protocol for a Mixed Methods Feasibility Study

Sean Lewis Hill

Background: The COVID-19 pandemic disrupted the delivery of diabetes care and worsened mental health among many patients with type 2 diabetes (T2D). This disruption puts patients with T2D at risk for poor diabetes outcomes, especially those who experience ...

JMIR PUBLICATIONS, INC2023

Blue Brain Nexus: An open, secure, scalable system for knowledge graph management and data-driven science

Henry Markram, Sean Lewis Hill, Samuel Claude Kerrien, Carolina Johanna Elisabeth Lindqvist, Alejandra Garcia Rojas Martinez, Huanxiang Lu, Mohameth François Sy, Anna-Kristin Kaufmann, Jonathan Raël Lurie, Henry Genet

Modern data-driven science often consists of iterative cycles of data discovery, acquisition, preparation, analysis, model building and validation leading to knowledge discovery as well as dissemination at scale. The unique challenges of building and simul ...

2023

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types

Sean Lewis Hill, Mohameth François Sy

The challenge of defining and cataloging the building blocks of the brain requires a standardized approach to naming neurons and organizing knowledge about their properties. The US Brain Initiative Cell Census Network, Human Cell Atlas, Blue Brain Project, ...

HUMANA PRESS INC2022

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt, Steven Petrou

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020

Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons

Henry Markram, Sean Lewis Hill, Ying Shi, Werner Alfons Hilda Van Geit, Christian O'Reilly, Christian Andreas Rössert, Elisabetta Iavarone, Bas-Jan Zandt, Jane Yi

Somatosensory thalamocortical (TC) neurons from the ventrobasal (VB) thalamus are central components in the flow of sensory information between the periphery and the cerebral cortex, and participate in the dynamic regulation of thalamocortical states inclu ...

2019

Reconstruction and simulation of neocortical microcircuitry

Henry Markram, Sean Lewis Hill, Eilif Benjamin Muller, Felix Schürmann

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for reconstructing and simulating neocortical microcircuitry. In one aspect, a method includes providing a model of neural tissue, the model including differ ...

2018

Towards a supervised classification of neocortical interneuron morphologies

Sean Lewis Hill, Ruth Benavides Piccione, Bojan Mihaljevic

BackgroundThe challenge of classifying cortical interneurons is yet to be solved. Data-driven classification into established morphological types may provide insight and practical value.ResultsWe trained models using 217 high-quality morphologies of rat so ...

2018

A Framework for Collaborative Curation of Neuroscientific Literature

Sean Lewis Hill, Elisabetta Iavarone, Christian O'Reilly

Large models of complex neuronal circuits require specifying numerous parameters, with values that often need to be extracted from the literature, a tedious and error-prone process. To help establishing shareable curated corpora of annotations, we have dev ...

Frontiers Research Foundation2017