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Mauro Delorenzi

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Related publications (38)

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Olivier Michielin, Etienne Meylan, Paolo Angelino, Mauro Delorenzi, Jessica Christine Vazquez, Pierre-Benoit Bernard Ancey, Stefania Crippa

Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components. W ...

2017

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Nadine Fournier, Etienne Meylan, Paolo Angelino, Jawahar Kopparam, Mauro Delorenzi, Alessandra Piersigilli, Johanna Pauline Chiffelle

Loss of epithelial differentiation and extracellular matrix (ECM) remodeling are known to facilitate cancer progression and are associated with poor prognosis in patients with lung cancer. We have identified Receptor-interacting serine/threonine protein ki ...

Nature Publishing Group2017

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Nadine Fournier, Mauro Delorenzi, Yan Agalarov, Esther Bovay

Biomechanical forces, such as fluid shear stress, govern multiple aspects of endothelial cell biology. In blood vessels, disturbed flow is associated with vascular diseases, such as atherosclerosis, and promotes endothelial cell proliferation and apoptosis ...

American Society for Clinical Investigation2015

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Michel Aguet, Patrick Rodriguez, Mauro Delorenzi, Norbert Wiedemann, Pascale Anderle Pedone, Andreas Eduard Moor, Sylvie André Baflast, Frédérique Baruthio

BCL9/9L proteins enhance the transcriptional output of the beta-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9 ...

Elsevier Science Bv2015

The consensus molecular subtypes of colorectal cancer

Douglas Hanahan, Anguraj Sadanandam, Krisztian Homicsko, Sarah Gerster, Paolo Angelino, Mauro Delorenzi, Xin Wang

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international c ...

Nature Publishing Group2015

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Nadine Fournier, Mauro Delorenzi, Simone Ragusa, Stavros Milatos

The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation. However, the mechanisms of metastatic outgrowth in colorectal cancer remain a major chal ...

Elsevier2014

Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support

Philipp Bucher, Jacques Rougemont, Olivier Michielin, Mauro Delorenzi, Heinz Stockinger, Ioannis Xenarios, Amos Bairoch

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) was created in 1998 as an institution to foster excellence in bioinformatics. It is renowned worldwide for its databases and software tools, such as UniProtKB/Swiss-Prot, PROSITE, SWISS-MODEL, STRI ...

Oxford University Press2014

Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells

Nadine Fournier, Mauro Delorenzi, Nawal Houhou, Yan Agalarov

One of the key mechanisms linking cell signaling and control of gene expression is reversible phosphorylation of transcription factors. FOXC2 is a forkhead transcription factor that is mutated in the human vascular disease lymphedema-distichiasis and plays ...

Amer Soc Microbiology2013

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status (vol 124, pg 547, 2012)

Jocelyne Bloch, Mauro Delorenzi

Springer2013

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Jocelyne Bloch, Mauro Delorenzi

The methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methyl ...

Springer-Verlag2012

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MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status (vol 124, pg 547, 2012)

Jocelyne Bloch, Mauro Delorenzi

Springer2013

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Jocelyne Bloch, Mauro Delorenzi

Springer-Verlag2012

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Olivier Michielin, Etienne Meylan, Paolo Angelino, Mauro Delorenzi, Jessica Christine Vazquez, Pierre-Benoit Bernard Ancey, Stefania Crippa

2017

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Michel Aguet, Patrick Rodriguez, Mauro Delorenzi, Norbert Wiedemann, Pascale Anderle Pedone, Andreas Eduard Moor, Sylvie André Baflast, Frédérique Baruthio

Elsevier Science Bv2015