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Mauro Delorenzi

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Related publications (38)

Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

Olivier Martin, Bart Deplancke, Felix Naef, Jacques Rougemont, Laura Symul, Nicolas Jean Philippe Guex, Winship Herr, Mauro Delorenzi, Nouria Hernandez

Interactions of cell-autonomous circadian oscillators with diurnal cycles govern the temporal compartmentalization of cell physiology in mammals. To understand the transcriptional and epigenetic basis of diurnal rhythms in mouse liver genome-wide, we gener ...

Public Library Science2012

Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF

Mauro Delorenzi

Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppresso ...

2012

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib-A Phase II Trial

Mauro Delorenzi

Amplification of the epidermal growth factor receptor (EGFR) gene is one of the most common oncogenic alterations in glioblastoma (45%) making it a prime target for therapy. However, small molecule inhibitors of the EGFR tyrosine kinase showed disappointin ...

2011

The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence

Mauro Delorenzi

Gene expression-based prediction of genomic copy number aberrations in the chromosomal region 12q13 to 12q15 that is flanked by MDM2 and CDK4 identified Wnt inhibitory factor 1 (WIF1) as a candidate tumor suppressor gene in glioblastoma. WIF1 encodes a sec ...

2011

Rgtsp: a generalized top scoring pairs package for class prediction

Mauro Delorenzi, Vlad Popovici

A top scoring pair (TSP) classifier consists of a pair of variables whose relative ordering can be used for accurately predicting the class label of a sample. This classification rule has the advantage of being easily interpretable and more robust against ...

Oxford University Press2011

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas

Michel Aguet, Mauro Delorenzi, Norbert Wiedemann, Pascale Anderle Pedone, Sylvie André Baflast

Canonical Wnt signaling plays a critical role in stem cell maintenance in epithelial homeostasis and carcinogenesis. Here, we show that in the mouse this role is critically mediated by Bcl9/Bcl9l, the mammalian homologues of Legless, which in Drosophila is ...

American Association for Cancer Research2010

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Darlene Goldstein, Chenxu Zhao, Mauro Delorenzi, Li Zhang, Vlad Popovici, Jun Luo, Wen Luo, Wei Wang, Ying Liu, Jonathan Koh Boon Han

Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to gene ...

Nature Publishing Group2010

Effect of training-sample size and classification difficulty on the accuracy of genomic predictors

Mauro Delorenzi, Vlad Popovici

Introduction: As part of the MicroArray Quality Control (MAQC)-II project, this analysis examines how the choice of univariate feature-selection methods and classification algorithms may influence the performance of genomic predictors under varying degrees ...

2010

Relationship between estrogen receptor alpha location and gene induction reveals the importance of downstream sites and cofactors

Felix Naef, Mauro Delorenzi

BACKGROUND: To understand cancer-related modifications to transcriptional programs requires detailed knowledge about the activation of signal-transduction pathways and gene expression programs. To investigate the mechanisms of target gene regulation by hum ...

BioMed Central2009

Method for predicting the efficacy of cancer therapy

Mauro Delorenzi

The present invention relates to a method and a kit for predicting the efficacy of cancer therapy in a subject who has undergone or is undergoing chemotherapy treatment for cancer. ...

2009

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Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas

Michel Aguet, Mauro Delorenzi, Norbert Wiedemann, Pascale Anderle Pedone, Sylvie André Baflast

American Association for Cancer Research2010

Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF

Mauro Delorenzi

2012

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib-A Phase II Trial

Mauro Delorenzi

2011

Effect of training-sample size and classification difficulty on the accuracy of genomic predictors

Mauro Delorenzi, Vlad Popovici

2010

Rgtsp: a generalized top scoring pairs package for class prediction

Mauro Delorenzi, Vlad Popovici

Oxford University Press2011

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Darlene Goldstein, Chenxu Zhao, Mauro Delorenzi, Li Zhang, Vlad Popovici, Jun Luo, Wen Luo, Wei Wang, Ying Liu, Jonathan Koh Boon Han

Nature Publishing Group2010

Relationship between estrogen receptor alpha location and gene induction reveals the importance of downstream sites and cofactors

Felix Naef, Mauro Delorenzi

BioMed Central2009

Method for predicting the efficacy of cancer therapy

Mauro Delorenzi

The present invention relates to a method and a kit for predicting the efficacy of cancer therapy in a subject who has undergone or is undergoing chemotherapy treatment for cancer. ...

2009

Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

Olivier Martin, Bart Deplancke, Felix Naef, Jacques Rougemont, Laura Symul, Nicolas Jean Philippe Guex, Winship Herr, Mauro Delorenzi, Nouria Hernandez

Public Library Science2012

The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence

Mauro Delorenzi

2011