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Single-cell imaging of host-microbe interactions over time is impeded by cellular motility because the cells under scrutiny tend to migrate out of the imaging field. To overcome this technical challenge, we developed a microfluidic platform for imaging hun ...
During infection, microbial pathogens encounter phagocytic cells of the host innate immune system, such as macrophages and neutrophils. These encounters typically lead to uptake and killing of the bacteria by the host cell or, conversely, parasitization of ...
EPFL2016
L. monocytogenes is a Gram-positive intracellular pathogen that can cause serious disease, like septicemia and meningitis. It is detected in the cytosol by the innate immune system by sensing pathogen ligands. c-di-AMP has recently been shown to be one of ...
2011
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The impact of cellular individuality on host-microbe interactions is increasingly appreciated but studying the temporal dynamics of single-cell behavior in this context remains technically challenging. Here we present a microfluidic platform, InfectChip, t ...
