Publications by Georges Khazen

Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling

Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Jay Coggan, Georges Khazen, Judit Planas Carbonell, Elvis Boci, Nadir Roman Guerrero, Juan José García Cantero, Alessandro Enrico Foni

Understanding the intracellular dynamics of brain cells entails performing three-dimensional molecular simulations incorporating ultrastructural models that can capture cellular membrane geometries at nanometer scales. While there is an abundance of neuron ...

Oxford University Press (OUP)2024

Reconstruction and Simulation of Neocortical Microcircuitry

Anastasia Ailamaki, Henry Markram, Sean Lewis Hill, Eilif Benjamin Muller, Rodrigo de Campos Perin, Lida Kanari, Srikanth Ramaswamy, Vincent Delattre, Michael Reimann, Ying Shi

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

Distributor of neurons in a neocortical column

Henry Markram, Felix Schürmann, Georges Khazen, Martin Telefont

Computer-implemented methods, software, and systems for determining a distribution of neuronal cells across a portion of a brain are described. One computer-implemented method for determining a target distribution of one or more neuronal cells across a por ...

2014

General developmental health in the VPA-rat model of autism

Henry Markram, Kamila Markram, Georges Khazen, Mônica Regina Favre

Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological symptomology of autism, animal ...

Frontiers Research Foundation2013

Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons

Henry Markram, Felix Schürmann, Georges Khazen

The electrical diversity of neurons arises from the expression of different combinations of ion channels. The gene expression rules governing these combinations are not known. We examined the expression of twenty-six ion channel genes in a broad range of s ...

Public Library of Science2012

Predictive Engineering the Membrane Composition of Neocortical Neurons

Georges Khazen

The brain is the most mysterious and intricate biological structure known to man. It dominates the way we live, think, reason and behave. It is built of billions of neurons that communicate with each other through trillions of connections using electrical ...

EPFL2011