Stewart Cole

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Related publications (489)

Pyridomycin bridges the NADH- and substratebinding pockets of the enoyl reductase InhA

Stewart Cole, Florence Pojer, Ruben Hartkoorn, Joao Pedro De Almeida Neres

Pyridomycin, a natural product with potent antituberculosis activity, inhibits a major drug target, the InhA enoyl reductase. Here, we unveil the co-crystal structure and unique ability of pyridomycin to block both the NADH cofactor- and lipid substrate-bi ...

Nature Publishing Group2014

Defining the origins and spread of leprosy using molecular biomarkers

Stewart Cole

Wiley-Blackwell2014

A structure-guided fragment-based approach was used to target the lipophilic allosteric binding site of Mycobacterium tuberculosis EthR. This elongated channel has many hydrophobic residues lining the binding site, with few opportunities for hydrogen bondi ...

Portland Press Ltd2014

Who will develop new antibacterial agents?

Stewart Cole

The golden age of antimicrobial drug development is a distant memory, and the likelihood of there being another seems slim. In part, this is because the pharmaceutical industry, which has now adopted an unsustainable business model, abandoned the anti-infe ...

Royal Soc2014

The Physics of the B Factories

Jian Wang, Olivier Schneider, Yiming Li, Varun Sharma, Aurelio Bay, Frédéric Blanc, Stewart Cole, Xin Chen, Mingkui Wang, Zhirui Xu, Chao Wang, Tagir Aushev, Lei Zhang, Yixing Chen, Ho Ling Li, Greig Alan Cowan, Tao Huang, Maurizio Martinelli, Vladislav Balagura, Liang Sun, Jean Wicht, Sun Hee Kim, Songmei Wu, Jun Yong Kim, Junqiu Liu, Remi Léandre Albert Louvot, Albert Perez, Jie Chen, Doohyun Kim, Yuan Yuan, Martin George Friedl, Yan Yan, Fang Liu, Guillaume Wagner, John Wilson, Bingqing Cheng, Patricia Besson, Jérôme Krebs, Nicolas Zwahlen, Hideki Konishi, Marc Kunze, Christian Jacoby, Nicolas Berger, Ji Hyun Kim, Dipanwita Dutta, Sanjeev Kumar, Geng Chen, Yi Wang, Hao Liu, Sourav Sen, Gerhard Raven, Xiao Wang, Kai Yi, Jing Li, Zhen Liu, Long Wang, Yu Zheng, Chen Chen, Xuan Li, François Bianchi, Weitao Wang, Zhi Zheng

Springer2014

Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion In Vitro Does Not Always Correlate with Attenuation of Virulence

Stewart Cole, Neeraj Dhar, Florence Pojer, Ming Zhang, Jan Lars Rybniker, Jeffrey Chen, Anna De Graff Tischler

The EspA protein of Mycobacterium tuberculosis is essential for the type VII ESX-1 protein secretion apparatus, which delivers the principal virulence factors ESAT-6 and CFP-10. In this study, site-directed mutagenesis of EspA was performed to elucidate it ...

American Society for Microbiology2013

Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence

Stewart Cole, Neeraj Dhar, Florence Pojer, Stefanie Boy-Röttger, Ming Zhang, Jan Lars Rybniker, Jeffrey Chen

The type-VII ESX-1 secretion apparatus, encoded by the esx-1 genetic locus, is essential for the export of EsxA and EsxB, two major virulence factors of Mycobacterium tuberculosis. ESX-1 also requires the products of the unlinked espACD operon for optimal ...

Wiley-Blackwell2013

Biomarkers are indispensable to the development of new tuberculosis therapeutics and vaccines. The most robust biomarkers measure factors that are essential to the underlying pathological process of the disease being treated, and thus can capture the full ...

Elsevier Science Inc2013

Drug-resistant tuberculosis: time for visionary political leadership

Stewart Cole

Two decades ago, WHO declared tuberculosis a global emergency, and invested in the highly cost-effective directly observed treatment short-course programme to control the epidemic. At that time, most strains of Mycobacterium tuberculosis were susceptible t ...

Elsevier2013

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Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have obtained genome sequences of Mycobacterium leprae from skeletons of five medieval leprosy cases from the United Kingdom, Sweden, and Denmark. In one case, the DNA was so ...

Amer Assoc Advancement Science2013

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