Stewart Cole

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Phi29 polymerase based random amplification of viral RNA as an alternative to random RT-PCR

Stewart Cole, Iain Old

BACKGROUND: Phi29 polymerase based amplification methods provides amplified DNA with minimal changes in sequence and relative abundance for many biomedical applications. RNA virus detection using microarrays, however, can present a challenge because phi29 ...

2008

Rising standards for tuberculosis drug development

Stewart Cole

Development of new drugs to treat tuberculosis (TB) faces even more constraints than the development of therapeutic agents for other diseases. This is due, in part, to intrinsic properties of the tubercle bacillus, such as its slow growth, phenotypic drug ...

2008

Comprehensive proteome analysis of Mycobacterium ulcerans and quantitative comparison of mycolactone biosynthesis

Stewart Cole, Petra Tafelmeyer

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a rapidly emerging human disease in which mycolactone, a cytotoxic and immunosuppressive macrocyclic polyketide, is responsible for massive skin destruction. The genome sequencing of M. ulceran ...

2008

Buruli ulcer is an emerging human disease caused by infection with a slow-growing pathogen, Mycobacterium ulcerans, that produces mycolactone, a cytotoxin with immunomodulatory properties. The disease is associated with wetlands in certain tropical countri ...

2008

Study of the decay mechanism for B+ -> p(p)over-barK(+) and B+ -> p(p)over-bar pi(+)

Olivier Schneider, Aurelio Bay, Stewart Cole, Mingkui Wang, Chao Wang, Tagir Aushev, Vladislav Balagura

We study the characteristics of the low mass p (p) over bar enhancements near threshold in the three-body decays B+ -> p (p) over barK(+) and B+ -> p (p) over bar pi(+). We observe that the proton polar angle distributions in the p (p) over bar helicity fr ...

2008

Study of B→D**lν with full reconstruction tagging

Olivier Schneider, Aurelio Bay, Stewart Cole, Mingkui Wang, Chao Wang, Tagir Aushev, Vladislav Balagura, Xiao Wang

2008

Difference in direct charge-parity violation between charged and neutral B meson decays

Olivier Schneider, Aurelio Bay, Stewart Cole, Mingkui Wang, Chao Wang, Tagir Aushev, Vladislav Balagura, Jean Wicht, Sun Hee Kim, Jing Li

2008

New medicines for tuberculosis (NM4TB)

Stewart Cole

2008

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential

Stewart Cole, Pablo Fernandez

Reversible protein phosphorylation is a major regulation mechanism of fundamental biological processes, not only in eukaryotes but also in bacteria. A growing body of evidence suggests that Ser/Thr phosphorylation play important roles in the physiology and ...

2007

The 6-kDa early secreted antigenic target ESAT-6 and the 10-kDa culture filtrate protein CFP-10 of Mycobacterium tuberculosis are secreted by the ESX-1 system into the host cell and thereby contribute to pathogenicity. Although different studies performed ...

2007

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Comprehensive proteome analysis of Mycobacterium ulcerans and quantitative comparison of mycolactone biosynthesis

Stewart Cole, Petra Tafelmeyer

2008

New medicines for tuberculosis (NM4TB)

Stewart Cole

2008

2007

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

Stewart Cole

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity

Stewart Cole