Stewart Cole

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The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

Stewart Cole

Mycobacterium leprae protein ML2640c belongs to a large family of conserved hypothetical proteins predominantly found in mycobacteria, some of them predicted as putative S-adenosylmethionine (AdoMet)-dependent methyltransferases (MTase). As part of a Struc ...

2007

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone

Stewart Cole

Mycolactone is a polyketide toxin produced by Mycobacterium ulcerans (Mu), the causative agent of the skin disease Buruli ulcer (BU). Surprisingly, infected tissues lack inflammatory infiltrates. Structural similarities between mycolactone and immunosuppre ...

2007

Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

Stewart Cole

Mycobacterium ulcerans is found in aquatic ecosystems and causes Buruli ulcer in humans, a neglected but devastating necrotic disease of subcutaneous tissue that is rampant throughout West and Central Africa. Here, we report the complete 5.8-Mb genome sequ ...

2007

Towards new tuberculosis drugs

Stewart Cole

The need for better drugs to treat tuberculosis has never been greater. Despite insufficient funding for discovery research, intensive efforts have been made to find and develop new lead compounds capable of reducing the duration of the present treatment k ...

2007

Improved measurement of CP-violating parameters in B→ρ+ρ- decays

Olivier Schneider, Stewart Cole, Mingkui Wang, Chao Wang, Tagir Aushev

We present a measurement of the CP-violating asymmetry in B0→ρ+ρ- decays using 535×106 BB̄ pairs collected with the Belle detector at the KEKB e+e- collider. We measure CP-violating coefficients A=0.16±0.21(stat)±0.08(syst) and S=0.19±0. 30(stat)±0.08(syst ...

2007

Search for B+→J/ψη′K+ and B0→J/ψη′KS0 decays

Olivier Schneider, Aurelio Bay, Stewart Cole, Mingkui Wang, Chao Wang, Tagir Aushev, Lei Zhang, Vladislav Balagura

We report the results of searches for B+→J/ψη′K+ and B0→J/ψη′KS0 decays, using a sample of 388×106 BB̄ pairs collected with the Belle detector at the Υ(4S) resonance. No statistically significant signal is found for either of the two decay modes and upper ...

2007

Observation of the decay B̄0→Ds+Λp̄

Olivier Schneider, Aurelio Bay, Stewart Cole, Chao Wang, Tagir Aushev, Vladislav Balagura

We report the first observation of the decay B̄0→Ds+Λ p̄ with a statistical significance of 6.6σ. We measure B(B̄0→Ds+Λp̄)=(2.9±0.7±0.5±0.4) ×10-5, where the first error is statistical, the second is systematic, and the third error comes from the uncertain ...

2007

Observation of direct CP violation in B0→π+π- decays and model-independent constraints on the quark-mixing angle 2

Olivier Schneider, Stewart Cole, Mingkui Wang, Chao Wang, Tagir Aushev, Lei Zhang

We report a new measurement of the time-dependent CP-violating parameters in B0→π+π- decays with 535×106 BB̄ pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider operating at the Υ(4S) resonance. We find 1464±65 B0→π+π- event ...

2007

Measurement of Einstein-Podolsky-Rosen-Type Flavor Entanglement in Υ(4S)→B0B¯0 Decays

Olivier Schneider, Aurelio Bay, Stewart Cole, Mingkui Wang, Chao Wang, Tagir Aushev, Jean Wicht, Sun Hee Kim, Christian Jacoby

2007

Search for Invisible Decay of the Υ(1S)

Olivier Schneider, Stewart Cole, Mingkui Wang, Chao Wang, Jean Wicht, Sun Hee Kim

2007

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The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

Stewart Cole

2007

Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

Stewart Cole

2007