Kristina Schoonjans

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The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

Kristina Schoonjans

TGR5 (Gpbar1) is a G protein-coupled receptor responsive to bile acids (BAs), which is expressed in different non-parenchymal cells of the liver, including biliary epithelial cells, liver-resident macrophages, sinusoidal endothelial cells (LSECs), and acti ...

2019

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Kristina Schoonjans, Bernard Schneider, Graham Knott, Davide D'Amico, Vera Monica Lemos Da Silva, Mario Romani, Hao Li, Vincenzo Sorrentino, Adrienne Joëlle Laurence Mottis, Francesca Potenza

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Kristina Schoonjans

A large number of glucagon-like-peptide-1(GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs s ...

AMER PHYSIOLOGICAL SOC2019

NTCP deficiency in mice protects against obesity and hepatosteatosis

Kristina Schoonjans

Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na+ taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma. R ...

AMER SOC CLINICAL INVESTIGATION INC2019

The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility

Kristina Schoonjans

In the ovary, follicular growth and maturation are complicated processes that involve a series of morphological and physiological changes in oocytes and somatic cells leading to ovulation and luteinization, essential processes for fertility. Given the comp ...

CELL PRESS2019

Crowd dynamics, Co-creation, and Values in technology innovation: a case study in robotics

Kristina Schoonjans, Gianluigi Viscusi

In this article I am going to analyze crowd dynamics in co-creation settings (Cordella, Paletti, & Maha, 2018; Ramaswamy & Ozcan, 2018; Viscusi & Tucci, 2018). Furthermore, I am going to investigate the connection between these dynamics and the values info ...

2019

A bioinspired synthetic niche enables culture of liver organoids suitable for clinical application

Kristina Schoonjans, Matthias Lütolf

WILEY2019

De novo NAD(+) synthesis enhances mitochondrial function and improves health

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Karim Laurent Gariani, Marika Olga Zietak

Nicotinamide adenine dinucleotide (NAD(+)) is a co-substrate for several enzymes, including the sirtuin family of NAD(+)-dependent protein deacylases. Beneficial effects of increased NAD(+) levels and sirtuin activation on mitochondrial homeostasis, organi ...

NATURE PUBLISHING GROUP2018

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

Kristina Schoonjans

2018

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Mitsunori Nomura, Thijs Pols, Laura Alejandra Velazquez Villegas, Marika Olga Zietak

2018

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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

Kristina Schoonjans

2018

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Kristina Schoonjans

AMER PHYSIOLOGICAL SOC2019

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Mitsunori Nomura, Thijs Pols, Laura Alejandra Velazquez Villegas, Marika Olga Zietak

2018