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Amalio Telenti

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Related publications (55)

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The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Jacques Fellay, Amalio Telenti, Istvan Bartha, Nimisha Chaturvedi

Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the heterozygous state, they test a gene's tolerance to haploinsufficiency and dominant loss of function. We a ...

Public Library Science2015

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Previous genome-wide association studies (GWAS) of HIV-1-infected populations have been underpowered to detect common variants with moderate impact on disease outcome and have not assessed the phenotypic variance explained by genome-wide additive effects. ...

Natl Acad Sciences2015

The Genomic Signature of Population Reconnection Following Isolation: From Theory to HIV

Amalio Telenti, Jeffrey David Jensen, Séverine Vuilleumier Varisco

Ease of worldwide travel provides increased opportunities for organisms not only to colonize new environments but also to encounter related but diverged populations. Such events of reconnection and secondary contact of previously isolated populations are w ...

Genetics Society of America2015

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Over the last few years, the vast progress in genome sequencing has highly increased the availability of genomic data. Today, individuals can obtain their digital genomic sequences at reasonable prices from many online service providers. Individuals can st ...

2015

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2015

Background: Social media platforms are increasingly seen as a source of data on a wide range of health issues. Twitter is of particular interest for public health surveillance because of its public nature. However, the very public nature of social media pl ...

2015

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Background: There is an ever-increasing volume of data on host genes that are modulated during HIV infection, influence disease susceptibility or carry genetic variants that impact HIV infection. We created GuavaH (Genomic Utility for Association and Viral ...

BioMed Central2014

In ecology, "disease tolerance" is defined as an evolutionary strategy of hosts against pathogens, characterized by reduced or absent pathogenesis despite high pathogen load. To our knowledge, tolerance has to date not been quantified and disentangled from ...

Public Library Science2014

LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection

Jacques Fellay, Amalio Telenti

Natural progression of HIV-1 infection depends on genetic variation in the human major histocompatibility complex (MHC) class I locus, and the CD8(+) T cell response is thought to be a primary mechanism of this effect. However, polymorphism within the MHC ...

Public Library of Science2014

Practical Solutions for Protecting Individual Genomic Privacy

Jean-Pierre Hubaux, Jacques Fellay, Mathias Jacques Jean-Marc Humbert, Amalio Telenti, Erman Ayday, Jean Louis Raisaro, Zhicong Huang, Paul Jack Mc Laren

The increasing availability of genomic data has major implications for personal privacy. The issues raised by genomic privacy reside at the crossroads of medicine, computer science, legislation and public policy. We here describe the design and development ...

2014