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A remotely powered fully integrated low power class-E power amplifier for implantable sensor systems

Catherine Dehollain, Enver Gürhan Kilinç, Kerim Türe

This paper presents a fully integrated low power class-E power amplifier and its integration to remotely powered sensor system. The on-chip 1.2 GHz power amplifier is implemented in 0.18 A mu m CMOS process with 0.2 V supply. The implantable system is powered by using an inductively coupled remote powering link at 13.56 MHz. A passive full-wave rectifier converts the induced AC voltage on the implant coil into a DC voltage. A clean and stable 1.8 V supply voltage for the sensor and communication blocks is generated by a voltage regulator. On-off keying modulated low-power transmitter at 1.2 GHz is used for the transmission of the data collected from the sensors. The transmitter is composed of a LC tank oscillator and a fully on-chip class-E power amplifier. Compared to the conventional class-E power amplifiers, an additional network which reduces the on-chip area is used at the output of the power amplifier. The measurement results verify the functionality of the remotely powered implantable sensor system and the power amplifier. The integrated power amplifier provides -10 dBm output power for 50 Omega load with a drain efficiency of 31.5 %. The uplink data communication with a data rate of 600 kbps is established by using a commercial 50 Omega chip antenna at 1 m communication distance.

Springer2016

In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism

Camilla Baj-Rossi, Sandro Carrara, Andrea Cavallini, Giovanni De Micheli, Catherine Dehollain, Enver Gürhan Kilinç, Francesca Stradolini

This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues on biocompatibility, three different covers have been designed, realized and tested in mice for 30 days. ATP and neutrophil concentrations have been measured, at the implant site after the device was explanted, to assess the level of biocompatibility of the device. Finally, fully working prototypes of the device were implanted in mice and tested. The implanted devices were used to detect variations in the physiological concentrations of glucose and paracetamol. Data trends on these analytes have been successfully acquired and transmitted to the external base station. Glucose and paracetamol (also named acetaminophen) have been proposed in this research as model molecules for applications to personalized and translational medicine.

Ieee-Inst Electrical Electronics Engineers Inc2016

Remotely powered PPM demodulator by inductive coupling for rodent applications

Catherine Dehollain, Enver Gürhan Kilinç, Franco Maloberti, Kerim Türe

A low-power pulse position modulation (PPM) demodulator has been developed for remotely powered batteryless implantable devices. The required power for the implantable device is provided by the magnetic coupling with the external array of powering of coils placed under the living space of the animal. The remote powering is turned off 6 % of one bit duration during data transmission. The remote powering link is optimized to deliver power at 13.56 MHz frequency. The power is transferred from 30 mm distance with 21 % efficiency. An integrated full-wave rectifier and voltage regulator generate 1.8 V supply voltage from induced signal. The integrated PPM demodulator consumes only 27.8 lW and has 8.33 kb/s data rate. The presented entire system and basic blocks are integrated using a 0.18 mu m CMOS technology. Experimental results verify the effectiveness of the PPM demodulator and the downlink communication system.

Springer Verlag2016