Johan Auwerx

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Related publications (283)

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

Johan Auwerx, Xiaoxu Li, Jia Liu, Qi Wang, Sandra Rodriguez Lopez, Keno Strotjohann

Background & Aims: Recent findings reveal the importance of tryptophan-initiated de novo nicotinamide adenine dinucleotide (NAD+) synthesis in the liver, a process previously considered secondary to biosynthesis from nicotinamide. The enzyme α-amino-β-carb ...

2025

A Multiomic Network Approach to Uncover Disease Modifying Mechanisms of Inborn Errors of Metabolism

Johan Auwerx

For many inborn errors of metabolism (IEM) the understanding of disease mechanisms remains limited, in part explaining their unmet medical needs. The expressivity of IEM disease phenotypes is affected by disease-modifying factors, including rare and common ...

2025

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Xiaoxu Li, Jia Liu, Maroun Bou Sleiman, Wen Gao, Amélia Lalou, Alessia De Masi, Jean-David Horacio Morel

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Johan Auwerx, Laurent Mouchiroud, Xiaoxu Li, Maroun Bou Sleiman, Elena Katsyuba, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam, Jean-David Horacio Morel

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Cellpose training data and scripts from "Inhibition of CERS1 in aging skeletal muscle exacerbates age-related muscle impairments"

Johan Auwerx, Olivier Burri, Martin Rainer Wohlwend

This Workflow contains all the material necessary to reproduce the results of the QuPath analysis performed in the paper "Inhibition of CERS1 in aging skeletal muscle exacerbates age-related muscle impairments" Inside this workflow and dataset, you will f ...

Zenodo2024

Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair

Johan Auwerx, Kristina Schoonjans

The mammalian sirtuin family (SIRT1-SIRT7) has shown diverse biological roles in the regulation and maintenance of genome stability under genotoxic stress. SIRT7, one of the least studied sirtuin, has been demonstrated to be a key factor for DNA damage res ...

2024

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Johan Auwerx, Kristina Schoonjans, Pan Xu

Aims: Sirtuin 7 (SIRT7) plays an important role in tumor development, and has been characterized as a potent regulator of cellular stress. However, the effect of SIRT7 on sorafenib acquired resistance remains unclear and a possible anti-tumor mechanism bey ...

2024

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Hadrien Charles Edouard Demagny, Antoine Jalil

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

2024

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Johan Auwerx

Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in phytoconstituents, present a useful resource for discovering therapies that could target senescence and thus improve he ...

2024

Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

Johan Auwerx, Xiaoxu Li, Alessia De Masi, Tanes Imamura de Lima, Keno Strotjohann

Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progress ...

Wiley2024

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