Publications by Riccardo Balzan

Pyruvate cellular uptake and enzymatic conversion probed by dissolution DNP-NMR: the impact of overexpressed membrane transporters

Arnaud Comment, Paul Romeo Vasos, Riccardo Balzan

Pyruvate membrane crossing and its lactate dehydrogenase-mediated conversion to lactate in cells featuring different levels of expression of membrane monocarboxylate transporters (MCT4) were probed by dissolution dynamic nuclear polarization-enhanced NMR. ...

Wiley2017

Hyperpolarized 6Li as a probe for hemoglobin oxygenation level

Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment, Ruud van Heeswijk, Riccardo Balzan

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation o ...

Wiley-Blackwell2016

Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR

Arnaud Comment, Paul Romeo Vasos, Riccardo Balzan

The main limitation of NMR-based investigations is low sensitivity. This prompts for long acquisition times, thus preventing real-time NMR measurements of metabolic transformations. Hyperpolarization via dissolution DNP circumvents part of the sensitivity ...

Journal Of Visualized Experiments2016

High-Precision MRI Reconstruction Algorithm for 3D Sphere Packings

Daniele Mari, Arnaud Comment, Riccardo Balzan, Alessandro Luigi Sellerio

Packings of granular materials are complex systems consisting of large sets of particles interacting via contact forces. Their internal structure is interesting for several theoretical and practical reasons, especially when the model system consists in a l ...

Springer Verlag2015

A link between short-range and long-range properties of random sphere packings

Daniele Mari, Gérard Gremaud, Arnaud Comment, Riccardo Balzan, Alessandro Luigi Sellerio

We present a high precision particle-by-particle 3D reconstruction of granular systems composed of monodispersed spheres (sphere packings); the experimental approach is based on magnetic resonance imaging techniques. Our measurements revealed a strong corr ...

Springer Berlin Heidelberg2013

Accurate fast low-angle solid-state nuclear polarization measurement

Andrea Capozzi, Tian Cheng, Arnaud Comment, Riccardo Balzan

2013

13C DNP efficiency in function of the glassing matrix content at different magnetic fields

Andrea Capozzi, Tian Cheng, Arnaud Comment, Riccardo Balzan

2013

Over 35% liquid-state 13C polarization via dissolution dynamic nuclear polarization at 7 T and 1 K with ubiquitous nitroxyl radicals

Andrea Capozzi, Tian Cheng, Arnaud Comment, Yuhei Takado, Riccardo Balzan

The most versatile method to increase liquid-state 13C NMR sensitivity is dissolution dynamic nuclear polarization. The use of trityl radicals is usually required to obtain very large 13C polarization via this technique. We herein demonstrate that up to 35 ...

Royal Soc Chemistry2013

Over 35% of liquid-state 13C polarization enhanced by TEMPOL via high field dissolution dynamic nuclear polarization

Andrea Capozzi, Tian Cheng, Arnaud Comment, Yuhei Takado, Riccardo Balzan

2013

Methods for Molecular Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy using Hyperpolarized Nuclei

Riccardo Balzan

Since the introduction 10 years ago of the dissolution method, Dynamic Nuclear Polarization (DNP) became a widely applied and powerful technique to enhance nuclear magnetic resonance (NMR) signals of low naturally abundant, insensitive nuclear spins for an ...

EPFL2013