Publications by Maurizio Molinari

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A simple tool to measure spasticity in spinal cord injury subjects

Maurizio Molinari, Arash Arami, Etienne Burdet

This work presents a wearable device and the algorithms for quantitative modelling of joint spasticity and its application in a pilot group of subjects with different levels of spinal cord injury. The device comprises light-weight instrumented handles to m ...

IEEE2017

Quality control mechanisms of protein biogenesis: proteostasis dies hard

Maurizio Molinari

The biosynthesis of proteins entails a complex series of chemical reactions that transform the information stored in the nucleic acid sequence into a polypeptide chain that needs to properly fold and reach its functional location in or outside the cell. It ...

Amer Inst Mathematical Sciences-Aims2016

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Maurizio Molinari

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the unfolded protein response (UPR). The UPR enhances production of ER-resident chaperones and enzym ...

Nature Publishing Group2016

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

Maurizio Molinari

Only native polypeptides are released from the endoplasmic reticulum (ER) to be transported at the site of activity. Persistently misfolded proteins are retained and eventually selected for ER-associated degradation (ERAD). The paradox of a structure-based ...

Amer Soc Cell Biology2015

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

Maurizio Molinari

Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. PrP is a glycosylated and disulfid ...

Amer Soc Biochemistry Molecular Biology Inc2015

N-linked sugar-regulated protein folding and quality control in the ER

Maurizio Molinari

Asparagine-linked glycans (N-glycans) are displayed on the majority of proteins synthesized in the endoplasmic reticulum (ER). Removal of the outermost glucose residue recruits the lectin chaperone malectin possibly involved in a first triage of defective ...

Academic Press Ltd- Elsevier Science Ltd2015

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides

Maurizio Molinari

The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins in eukaryotic cells. The lumen of the mammalian ER contains >20 members of the protein disulfide isomerase (PDI) superfamily, which ensure formation of the correct ...

Amer Soc Cell Biology2015

Proteostasis: Bad news and good news from the endoplasmic reticulum

Maurizio Molinari

The endoplasmic reticulum (ER) is an intracellular compartment dedicated to the synthesis and maturation of secretory and membrane proteins, totalling about 30% of the total eukaryotic cells proteome. The capacity to produce correctly folded polypeptides a ...

E M H Swiss Medical Publishers Ltd2014

How Viruses Hijack the ERAD Tuning Machinery

Maurizio Molinari, Riccardo Bernasconi

An essential step during the intracellular life cycle of many positive-strand RNA viruses is the rearrangement of host cell membranes to generate membrane-bound replication platforms. For example, Nidovirales and Flaviviridae subvert the membrane of the en ...

Amer Soc Microbiology2014

Maurizio Molinari

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A simple tool to measure spasticity in spinal cord injury subjects

Quality control mechanisms of protein biogenesis: proteostasis dies hard

Five Questions (with their Answers) on ER-Associated Degradation

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

N-linked sugar-regulated protein folding and quality control in the ER

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides

Proteostasis: Bad news and good news from the endoplasmic reticulum

How Viruses Hijack the ERAD Tuning Machinery

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

N-linked sugar-regulated protein folding and quality control in the ER

A simple tool to measure spasticity in spinal cord injury subjects

Quality control mechanisms of protein biogenesis: proteostasis dies hard

Five Questions (with their Answers) on ER-Associated Degradation

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides

Proteostasis: Bad news and good news from the endoplasmic reticulum

How Viruses Hijack the ERAD Tuning Machinery