Publications de Maurizio Molinari

A simple tool to measure spasticity in spinal cord injury subjects

Maurizio Molinari, Arash Arami, Etienne Burdet

This work presents a wearable device and the algorithms for quantitative modelling of joint spasticity and its application in a pilot group of subjects with different levels of spinal cord injury. The device comprises light-weight instrumented handles to m ...

IEEE2017

Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?

Maurizio Molinari

Amplification of the candidate oncogene TLOC1/SEC62 in tumors correlates with reduced patient survival. The recently reported role of SEC62 as an autophagy receptor that controls endoplasmic reticulum (ER) size and function might open new scenarios for und ...

Taylor & Francis Inc2017

Quality control mechanisms of protein biogenesis: proteostasis dies hard

Maurizio Molinari

The biosynthesis of proteins entails a complex series of chemical reactions that transform the information stored in the nucleic acid sequence into a polypeptide chain that needs to properly fold and reach its functional location in or outside the cell. It ...

Amer Inst Mathematical Sciences-Aims2016

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Maurizio Molinari

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the unfolded protein response (UPR). The UPR enhances production of ER-resident chaperones and enzym ...

Nature Publishing Group2016

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides

Maurizio Molinari

The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins in eukaryotic cells. The lumen of the mammalian ER contains >20 members of the protein disulfide isomerase (PDI) superfamily, which ensure formation of the correct ...

Amer Soc Cell Biology2015

N-linked sugar-regulated protein folding and quality control in the ER

Maurizio Molinari

Asparagine-linked glycans (N-glycans) are displayed on the majority of proteins synthesized in the endoplasmic reticulum (ER). Removal of the outermost glucose residue recruits the lectin chaperone malectin possibly involved in a first triage of defective ...

Academic Press Ltd- Elsevier Science Ltd2015

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

Maurizio Molinari

Only native polypeptides are released from the endoplasmic reticulum (ER) to be transported at the site of activity. Persistently misfolded proteins are retained and eventually selected for ER-associated degradation (ERAD). The paradox of a structure-based ...

Amer Soc Cell Biology2015

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

Maurizio Molinari

Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. PrP is a glycosylated and disulfid ...

Amer Soc Biochemistry Molecular Biology Inc2015

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Maurizio Molinari

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

A simple tool to measure spasticity in spinal cord injury subjects

Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?

Quality control mechanisms of protein biogenesis: proteostasis dies hard

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Five Questions (with their Answers) on ER-Associated Degradation

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides

N-linked sugar-regulated protein folding and quality control in the ER

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

Graph Chatbot

Chattez avec Graph Search

Quality control mechanisms of protein biogenesis: proteostasis dies hard

Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides

N-linked sugar-regulated protein folding and quality control in the ER

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

Five Questions (with their Answers) on ER-Associated Degradation

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

A simple tool to measure spasticity in spinal cord injury subjects

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery