Richardus Houtkooper

This person is no longer with EPFL

About
Privacy
Disclaimer

Graph Chatbot

Related publications (30)

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper, Jie Zhang

The most important physiological mechanism mediating enhanced exercise performance is increased sympathetic, beta adrenergic receptor (beta-AR), and adenylyl cyclase (AC) activity. This is the first report of decreased AC activity mediating increased exerc ...

Wiley-Blackwell2015

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "ba ...

American Association for Cancer Research2015

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Johan Auwerx, Bart Deplancke, Richardus Houtkooper, Laurent Mouchiroud, Dongryeol Ryu, Xu Wang, Evan Graehl Williams, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Norman Lionel Moullan

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here tha ...

Elsevier2015

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper, Pénélope Andreux, Xu Wang, Adrienne Joëlle Laurence Mottis, Norman Lionel Moullan, Virginija Jovaisaite, Sabrina Bichet

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has pro ...

Nature Publishing Group2014

Mitonuclear protein imbalance as a conserved longevity mechanism

Johan Auwerx, Graham Knott, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

Methods of treating mitochondrial dysfunction

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging. ...

2013

Pharmacological approaches to restore mitochondrial function

Johan Auwerx, Pénélope Andreux, Richardus Houtkooper

Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but also implicated in age-related diseases, including those that affect the metabolic and nervous system, such as type 2 diabetes and Parkinson's disease. Numerous ...

Nature Publishing Group2013

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

2013

Aging biomarkers

Johan Auwerx, Richardus Houtkooper

The present invention relates to novel biomarkers for aging and healthspan, methods and uses thereof, in particular, for determining the biological age of a subject and/or preventing or delaying aging process in a subject, and kits for use in said methods. ...

2013

The RNA-binding protein Imp2 regulates oxidative phosporylation that is key to glioblastoma cancer stem cell maintenance

Richardus Houtkooper, Ivan Stamenkovic, Michalina Janiszewska

Federation Amer Soc Exp Biol2012

Page 2 of 3