Publications de Richardus Houtkooper

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Johan Auwerx, Richardus Houtkooper, Dongryeol Ryu, Xu Wang

Recently, several studies have demonstrated that tetracyclines, the antibiotics most intensively used in livestock and that are also widely applied in biomedical research, interrupt mitochondrial proteostasis and physiology in animals ranging from round wo ...

Wiley-Blackwell2015

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Johan Auwerx, Laurent Mouchiroud, Pénélope Andreux, Richardus Houtkooper, Xu Wang, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Sabrina Bichet

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has pro ...

Nature Publishing Group2014

Mitonuclear protein imbalance as a conserved longevity mechanism

Johan Auwerx, Graham Knott, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

Pharmacological approaches to restore mitochondrial function

Johan Auwerx, Pénélope Andreux, Richardus Houtkooper

Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but also implicated in age-related diseases, including those that affect the metabolic and nervous system, such as type 2 diabetes and Parkinson's disease. Numerous ...

Nature Publishing Group2013

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis

NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further red ...

Cell Press2013

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

2013

Methods of treating mitochondrial dysfunction

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging. ...

2013

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Johan Auwerx, Richardus Houtkooper, Ivan Stamenkovic, Michalina Janiszewska

Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. ...

Cold Spring Harbor Lab Press, Publications Dept2012

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Richardus Houtkooper

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Mitonuclear protein imbalance as a conserved longevity mechanism

Pharmacological approaches to restore mitochondrial function

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mitochondrial ribosomal proteins as aging regulators

Methods of treating mitochondrial dysfunction

Aging biomarkers

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

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Chattez avec Graph Search

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Methods of treating mitochondrial dysfunction

Mitochondrial ribosomal proteins as aging regulators

Aging biomarkers

Pharmacological approaches to restore mitochondrial function

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Mitonuclear protein imbalance as a conserved longevity mechanism

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research