Person
Matteo Cornaglia
Related publications (41)
Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Laurent Mouchiroud, Abdul Jabbar
As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant-derived rotenoid, selectively a ...
Federation Amer Soc Exp Biol2017A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput
Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Laurent Mouchiroud, Hüseyin Baris Atakan
We present a multiplexed and automated microfluidic platform for phenotyping of C. elegans during their full lifespan and at high-throughput. We used the fluorescent hsp-6::gfp strain of worms and performed experiments to observe the effect of four differe ...
2017An Integrated Microfluidic Device For C-Elegans Early Embryogenesis Studies And Drug Assays
Martinus Gijs, Pierre Gönczy, Thomas Lehnert, Matteo Cornaglia, Li Dong, Radek Jankele, Jingwei Zhang
The Caenorhabditis elegans embryo is a widely used model for the functional analysis of dynamic cellular processes, such as chromosome segregation, cytokinesis or lineage analysis. However, the conventional embryo preparation method that relies on manually ...
Ieee2017Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans
Martinus Gijs, Thomas Lehnert, Matteo Cornaglia
In a typical high-throughput drug screening (HTS) process, up to millions of chemical compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit a robust dose-response, as evidenced for example by a fluorescence signal. I ...
Royal Soc Chemistry2017Sensitive and inexpensive digital DNA analysis by microfluidic enrichment of rolling circle amplified single-molecules
Martinus Gijs, Matteo Cornaglia
Single molecule quantification assays provide the ultimate sensitivity and precision for molecular analysis. However, most digital analysis techniques, i.e. droplet PCR, require sophisticated and expensive instrumentation for molecule compartmentalization, ...
Oxford University Press (OUP)2017C. Elegans Immobilization Using Deformable Microfluidics For In Vivo Studies Of Early Embryogenesis And Intestinal Microbiota
Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong, Xiaopeng Huang, Jingwei Zhang
The genome of the nematode Caenorhabditis elegans shows far-reaching similarities to that of humans. C. elegans is therefore considered as a powerful model organism in biological research related to humans, for instance for the study of human diseases. Suc ...
Ieee2017Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models
Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Vincenzo Sorrentino, Govindan Narayanan Krishnamani
Background: While many biological studies can be performed on cell-based systems, the investigation of molecular pathways related to complex human dysfunctions - e.g. neurodegenerative diseases - often requires long-term studies in animal models. The nemat ...
BioMed Central2016System for optical detection and imaging of sub-diffraction-limited nano-objects
Martinus Gijs, Matteo Cornaglia, Hui Yang
Nano-objects (8) with feature size smaller than the classical Abbe's diffraction limit can be optically detected via a microlens (4) array configured in a miniaturized microfluidic device. A hydrophilic microwell (3) array in a hydrophobic layer (2) is fir ...
2016Versatile size-dependent sorting of C-elegans nematodes and embryos using a tunable microfluidic filter structure
Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong
The roundworm Caenorhabditis elegans (C. elegans) is a powerful model organism for addressing fundamental biological questions related to human disease and aging. Its life cycle consists of an embryo stage, four larval stages that can be clearly distinguis ...
Royal Soc Chemistry2016On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites
Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong
Like other animals, C. elegans nematodes have the ability to socially interact and to communicate through exchange and sensing of small soluble signaling compounds that help them cope with complex environmental conditions. For the time being, worm biocommu ...
Royal Soc Chemistry2016