Person
Tom Hilbert
Related publications (41)
Normal volumetric and T1 relaxation time values at 1.5 T in segmented pediatric brain MRI using a MP2RAGE acquisition
Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Bénédicte Marie Maréchal, Gian Franco Piredda
Objectives This study introduced a tailored MP2RAGE-based brain acquisition for a comprehensive assessment of the normal maturing brain. Methods Seventy normal patients (35 girls and 35 boys) from 1 to 16 years of age were recruited within a prospective mo ...
SPRINGER2020Probing myelin content of the human brain with MRI: A review
Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Gian Franco Piredda
Rapid and efficient transmission of electric signals among neurons of vertebrates is ensured by myelin-insulating sheaths surrounding axons. Human cognition, sensation, and motor functions rely on the integrity of these layers, and demyelinating diseases o ...
WILEY2020Comparison of 2D simultaneous multi-slice and 3D GRASE readout schemes for pseudo-continuous arterial spin labeling of cerebral perfusion at 3 T
Tobias Kober, Tom Hilbert, Bénédicte Marie Maréchal
Objective In this perfusion magnetic resonance imaging study, the performances of different pseudo-continuous arterial spin labeling (PCASL) sequences were compared: two-dimensional (2D) single-shot readout with simultaneous multislice (SMS), 2D single-sho ...
SPRINGER2020Model-informed machine learning for multi-component T2 relaxometry
Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Elda Fischi Gomez, Marco Pizzolato, Gian Franco Piredda, Thomas Yu, Cristina Granziera, Muhamed Barakovic
Recovering the distribution from multi-echo magnetic resonance (MR) signals is challenging but has high potential as it provides biomarkers characterizing the tissue micro-structure, such as the myelin water fraction (MWF). In this work, we propose to comb ...
2020Compressed sensing with signal averaging for improved sensitivity and motion artifact reduction in fluorine-19 MRI
Tobias Kober, Tom Hilbert, Jérôme Yerly, Ruud van Heeswijk, Elena Najdenovska
Fluorine-19 (F-19) MRI of injected perfluorocarbon emulsions (PFCs) allows for the non-invasive quantification of inflammation and cell tracking, but suffers from a low signal-to-noise ratio and extended scan time. To address this limitation, we tested the ...
WILEY2020Quantitative brain relaxation atlases for personalized detection and characterization of brain pathology
Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Gian Franco Piredda, Reto Meuli, Cristina Granziera, Guillaume Bonnier
Purpose To exploit the improved comparability and hardware independency of quantitative MRI, databases of MR physical parameters in healthy tissue are required, to which tissue properties of patients can be compared. In this work, normative values for long ...
WILEY2019Fast model-based T-2 mapping using SAR-reduced simultaneous multislice excitation
Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, José Pedro Rebelo Ferreira Marques
Purpose To obtain whole-brain high-resolution T-2 maps in 2 minutes by combining simultaneous multislice excitation and low-power PINS (power independent of number of slices) refocusing pulses with undersampling and a model-based reconstruction. Methods A ...
WILEY2019Model-based super-resolution reconstruction of T-2 maps
Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Gian Franco Piredda, Reto Meuli, Mohammad Golbabaee, Wajiha Bano
Purpose High-resolution isotropic T-2 mapping of the human brain with multi-echo spin-echo (MESE) acquisitions is challenging. When using a 2D sequence, the resolution is limited by the slice thickness. If used as a 3D acquisition, specific absorption rate ...
WILEY2019Magnetization transfer in magnetic resonance fingerprinting
Purpose To study the effects of magnetization transfer (MT, in which a semi-solid spin pool interacts with the free pool), in the context of magnetic resonance fingerprinting (MRF). Methods Simulations and phantom experiments were performed to study the im ...
WILEY2019Clinical equivalence assessment of T2 synthesized pediatric brain magnetic resonance imaging
Tobias Kober, Tom Hilbert, Jocelyn Philippe
Background and purpose. - Automated synthetic magnetic resonance imaging (MRI) provides qualitative, weighted image contrasts as well as quantitative information from one scan and is well-suited for various applications such as analysis of white matter dis ...
MASSON EDITEUR2019