Publications by Huanxiang Lu | EPFL Graph Search

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Henry Markram, Kathryn Hess Bellwald, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Lida Kanari, Ying Shi, Armando Romani, Adrien Michel Achille Devresse

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2024

Enhancement of brain atlases with region-specific coordinate systems: flatmaps and barrel column annotations

Michael Reimann, Armando Romani, Aleksandra Zuzanna Teska, Felix Schürmann, Juan Bautista Hernando Vieites, Huanxiang Lu, Sirio Bolaños Puchet

Digital brain atlases define a hierarchy of brain regions and their locations in three-dimensional space. They provide a standard coordinate system in which diverse datasets can be integrated for visualization and analysis. They also enable building of dat ...

2024

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Lida Kanari, Ying Shi, Armando Romani, Davide Bella, Felix Schürmann

The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, i ...

2024

Blue Brain Nexus: An open, secure, scalable system for knowledge graph management and data-driven science

Henry Markram, Sean Lewis Hill, Samuel Claude Kerrien, Carolina Johanna Elisabeth Lindqvist, Alejandra Garcia Rojas Martinez, Huanxiang Lu, Mohameth François Sy, Anna-Kristin Kaufmann, Jonathan Raël Lurie, Henry Genet

Modern data-driven science often consists of iterative cycles of data discovery, acquisition, preparation, analysis, model building and validation leading to knowledge discovery as well as dissemination at scale. The unique challenges of building and simul ...

2023

Supervised Learning With Perceptual Similarity for Multimodal Gene Expression Registration of a Mouse Brain Atlas

Henry Markram, Felix Schürmann, Daniel Keller, Huanxiang Lu, Francesco Casalegno, Csaba Erö, Dimitri Bruno Marie Rodarie

The acquisition of high quality maps of gene expression in the rodent brain is of fundamental importance to the neuroscience community. The generation of such datasets relies on registering individual gene expression images to a reference volume, a task en ...

FRONTIERS MEDIA SA2021

A null model of the mouse whole-neocortex micro-connectome

Henry Markram, Eilif Benjamin Muller, Michael Reimann, Ying Shi, Huanxiang Lu

In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale c ...

Nature Research2019

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Rolf Gruetter, Lijing Xin, Benoît Schaller, Kim Do, Huanxiang Lu

BACKGROUND: Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in the glutamate-cysteine ligase catalytic gene (GCLC), the rate-limiting ...

Oxford University Press2016

Genetic Association with Prefrontal Glutathione Deficit: A 3T 1H MRS Study in Early Psychosis

Rolf Gruetter, Lijing Xin, Kim Do, Huanxiang Lu

Elsevier Science Inc2014

Proton T(1) relaxation times of metabolites in human occipital white and gray matter at 7 T

Rolf Gruetter, Lijing Xin, Benoît Schaller, Huanxiang Lu

Proton T(1) relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T(1) values of CH(3) and CH(2) group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in o ...

Wiley-Blackwell2013