Publications by Dongryeol Ryu | EPFL Graph Search

Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu, Xu Wang, Adriano Maida

The nuclear receptor corepressor 1 (NCoR1) is a transcriptional co-regulator that has wide-ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits the activation of PPARα upon fee ...

Wiley-Blackwell2015

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu, Xu Wang, Adriano Maida

Nuclear receptor corepressor 1 (NCoR1) is a transcriptional coregulator that has wide-ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits activation of peroxisome proliferator ...

Wiley-Blackwell2015

Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Alessia Perino, Vera Monica Lemos Da Silva, Dongryeol Ryu, Xu Wang, Norman Lionel Moullan, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani

With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease inWestern countries and its worldwide prevalence continues to increase along with the growing obesity epidemic. Here, ...

Wiley-Blackwell2015

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Johan Auwerx, Richardus Houtkooper, Dongryeol Ryu, Xu Wang

Recently, several studies have demonstrated that tetracyclines, the antibiotics most intensively used in livestock and that are also widely applied in biomedical research, interrupt mitochondrial proteostasis and physiology in animals ranging from round wo ...

Wiley-Blackwell2015

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Hongbo Zhang, Matthias Alexander Sokrates Stein, Giuseppe Lo Sasso

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...

Cell Press2014

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Johan Auwerx, Kristina Schoonjans, Laurent Mouchiroud, Dongryeol Ryu, Alessandra Piersigilli, Elena Katsyuba, Giuseppe Lo Sasso

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Dongryeol Ryu, Xu Wang, Keir Joe Menzies, Chikage Mataki, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer, Pan Xu

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014

Hypothalamic S1P/S1PR1 axis controls energy homeostasis

Dongryeol Ryu

Sphingosine 1-phosphate receptor 1 (S1PR1) is a G-protein-coupled receptor for sphingosine-1-phosphate (S1P) that has a role in many physiological and pathophysiological processes. Here we show that the S1P/S1PR1 signalling pathway in hypothalamic neurons ...

Nature Publishing Group2014

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis

Johan Auwerx, Dongryeol Ryu, Eija Riitta Pirinen

No therapy for non-alcoholic steatohepatitis (NASH) has been approved so far. Roux-en-y gastric bypass (RYGB) is emerging as a therapeutic option, although its effect on NASH and related hepatic molecular pathways is unclear from human studies. We studied ...

2014

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Dongryeol Ryu

Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Hypothalamic S1P/S1PR1 axis controls energy homeostasis

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis

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Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease

Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Hypothalamic S1P/S1PR1 axis controls energy homeostasis

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis